Results 31 to 40 of about 319 (119)

An update on the development of novel antifungal agents for eumycetoma [PDF]

, 2023
Eumycetoma, a chronic subcutaneous mycosis, responds poorly to the available antifungal treatments and patients often require extensive surgical resection or amputation of the affected limb. More effective treatments are needed for eumycetoma.
Bonifaz, Alexandro, Chandler, David, van de Sande, Wendy   +2 more
core   +2 more sources

Selective cytotoxicity of dihydroorotate dehydrogenase inhibitors to human cancer cells under hypoxia and nutrient-deprived conditions [PDF]

, 2018
Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool.
Amalia, Eri, Harada, Shigeharu, Inaoka, Daniel, Kido, Yasutoshi, Kita, Kiyoshi, Miyazaki, Yuki, Moore, Anthony, Nakamura, Mari, Saimoto, Hiroyuki, Sakai, Chika, Sakura, Takaya, Shiba, Tomoo   +11 more
core   +3 more sources

Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope [PDF]

, 2019
Invasive Scedosporium spp. and Lomentospora prolificans infections are an emerging threat in immunocompromised and occasionally in healthy hosts. Scedosporium spp. is intrinsically resistant to most, L. prolificans to all the antifungal drugs currently
Aurbach U., Caggiano G., Chander J., Chedotal I., Cheng M. P., Cornely O. A., Denis J., Duarte R. F., Duran Graeff L., Hamprecht A., Herbrecht R., Kohler P., Lackner M., Los-Arcos I., Mares M., Meissner A., Mellinghoff S., Montagna M. T., Pakstis D. L., Piepenbrock E., Salmanton-Garcia J., Seidel D., Slavin M., Stecher M., Trauth J., Vehreschild J. J., Vehreschild M. J. G. T., Wisplinghoff H.   +27 more
core   +3 more sources

Clinical Relevance and Characteristics of Aspergillus calidoustus and Other Aspergillus Species of Section Usti. [PDF]

, 2020
The Aspergilli of section Usti (group ustus) are represented by over 20 species, of which Aspergillus calidoustus is the most relevant human pathogen. Invasive aspergillosis (IA) caused by these fungi is rare but could represent an emerging issue among ...
Erard, V., Glampedakis, E., Lamoth, F.
core   +1 more source

Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species [PDF]

, 2023
Olorofim is a new antifungal in clinical development which has a novel mechanism of action against dihydroorotate dehydrogenase (DHODH). DHODH form a ubiquitous family of enzymes in the de novo pyrimidine biosynthetic pathway and are split into class 1A,
Birch, Mike, Lebedinec, Ressa, Levine, Tim P, Oliver, Jason D, Pinder, Corinne   +4 more
core  

Hope on the horizon: Novel fungal treatments in development [PDF]

, 2020
The treatment of invasive fungal infections remains challenging due to limitations in currently available antifungal therapies including toxicity, interactions, restricted routes of administration, and drug resistance.
Coler-Reilly, Ariella, Larson, Lindsey, Rauseo, Adriana M, Spec, Andrej   +3 more
core   +1 more source

Management of cerebral azole-resistant Aspergillus fumigatus infection : a role for intraventricular liposomal-amphotericin B [PDF]

, 2020
Objectives: In the pre-azole era, central nervous system (CNS) infections with Aspergillus had a dismal outcome. Survival improved with voriconazole but CNS infections caused by azole-resistant Aspergillus fumigatus preclude its use.
Bredius, R. G. M., Bruggemann, R. J., Goemans, B. F., Rijnders, B. J. A., Schauwvlieghe, Alexander, Smiers, F. J. W., van der Beek, M. T., Verdijk, R. M., Zwaan, C. M.   +8 more
core   +2 more sources

Aspergillus fumigatus and aspergillosis: From basics to clinics [PDF]

, 2021
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by causing numerous invasive infections and a notable mortality in humans, especially in immunocompromised patients.
Aljohani, R, Arastehfar, A, Berman, J, Carvalho, A, Gabaldón, T, Garcia-Rubio, Rocio, Hedayati, MT, Hoenigl, M, Houbraken, J, Ilkit, M, Jacobsen, ID, James-Armstrong, D, Jenks, JD, Kostrzewa, M, Lass-Flörl, C, Lombardi, L, Meletiadis, J, Osherov, N, Pan, W, Perlin, D S, Rivero-Menendez, O   +20 more
core   +1 more source

Synthesis and Biological Evaluation of Novel 2‐(Piperidin‐4‐yl)‐1,2,3,4‐tetrahydroisoquinoline and 2‐(Piperidin‐4‐yl)decahydroisoquinoline Antimycotics

Archiv der Pharmazie, Volume 358, Issue 10, October 2025.
A series of 13 hybrid molecules of both lead structures were prepared using reductive amination as key reaction step. The antimycotic potency of the resulting compounds was evaluated against yeast and mold species. Two compounds showed remarkable potency against several yeasts, and even against Candida krusei.
Marie‐Christin Hain, Monika Klimt, Franz Bracher, Ulrike Binder, Jürgen Krauß   +4 more
wiley   +1 more source

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source