Results 21 to 30 of about 319 (119)
Superbugs or multidrug resistant microbes: A new threat to the society. [PDF]
Health Sci Rep, 2023 Health Science Reports, Volume 6, Issue 8, August 2023.
Painuli S, Semwal P, Sharma R, Akash S.
europepmc +2 more sources
Journal of Fungi, 2021 Olorofim is a novel antifungal drug that belongs to the orotomide drug class which inhibits fungal dihydroorotate dehydrogenase (DHODH), thus halting pyrimidine biosynthesis and ultimately DNA synthesis, cell growth and division. It is being developed at
Ourania Georgacopoulos +6 more
doaj +1 more source
Invasive pulmonary aspergillosis in the intensive care unit: current challenges and best practices
APMIS, Volume 131, Issue 11, Page 654-667, November 2023., 2023 The prevalence of invasive pulmonary aspergillosis (IPA) is growing in critically ill patients in the intensive care unit (ICU). It is increasingly recognized in immunocompetent hosts and immunocompromised ones. IPA frequently complicates both severe influenza and severe coronavirus disease 2019 (COVID‐19) infection.
Sarah Gaffney +4 more
wiley +1 more source
Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus [PDF]
, 2022 Aspergillosis, in its various manifestations, is a major cause of morbidity and mortality. Very few classes of antifungal drugs have been approved for clinical use to treat these diseases and resistance to the first-line therapeutic class, the triazoles ...
Amich, Jorge +8 more
core +3 more sources
Internal Medicine Journal, Volume 53, Issue 8, Page 1489-1491, August 2023., 2023 Abstract Scedosporium and Lomentospora species are environmental moulds that are virulent in immunocompromised hosts and rarely cause bloodstream infection (BSI). Patients with Scedosporium and Lomentospora species BSI were identified by the state public laboratory service in Queensland, Australia, over a 20‐year period.
Adam G. Stewart +5 more
wiley +1 more source
Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]
, 2020 Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E. +6 more
core +1 more source
Invasive aspergillosis in liver transplant recipients
Transplant Infectious Disease, Volume 25, Issue 3, June 2023., 2023 Abbreviations: Ciclos, cyclosporine; CNS, central nervous system; IA, invasive aspergillosis; ICU, intensive care unit; IS, immunosuppression; MELD, model for end‐stage liver disease; RBC, red blood cell; Tac, tacrolimus. aMultivariate analysis. *For invasive fungal infection. **For solid organ transplant.
Cléa Melenotte +11 more
wiley +1 more source
Madurella mycetomatis, the main causative agent of eumycetoma, is highly susceptible to olorofim [PDF]
, 2020 OBJECTIVES: Eumycetoma is currently treated with a combination of itraconazole therapy and surgery, with limited success. Recently, olorofim, the lead candidate of the orotomides, a novel class of antifungal agents, entered a Phase II trial for the ...
Birch, M. (Mike) +8 more
core +1 more source
In vitro activity of the novel antifungal compound F901318 against Australian Scedosporium and Lomentospora fungi [PDF]
Medical Mycology, 2018 We determined the in vitro activity of the novel orotomide antifungal, F901318, against 30 Lomentospora prolificans, 20 Scedosporium apiospermum, 7 S. aurantiacum, and 3 S. boydii, isolates in comparison with standard antifungals. Against L. prolificans, F901318 was the most potent compound (MIC90 0.25 μg/ml); the geometric mean MIC (0.26 μg/ml) was ...
Chayanika, Biswas +7 more
openaire +2 more sources
Treatment of Aspergillosis. [PDF]
, 2018 Infections caused by Aspergillus spp. remain associated with high morbidity and mortality. While mold-active antifungal prophylaxis has led to a decrease of occurrence of invasive aspergillosis (IA) in those patients most at risk for infection ...
Hoenigl, Martin, Jenks, Jeffrey D
core +1 more source