What is the role of microbial biotechnology and genetic engineering in medicine?
MicrobiologyOpen, Volume 13, Issue 2, April 2024.Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
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Antifungal resistance: current trends and future strategies to combat [PDF]
, 2017 Nathan P Wiederhold Department of Pathology and Laboratory Medicine, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Abstract: Antifungal resistance represents a major clinical challenge to ...
Nathan Wiederhold
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The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment [PDF]
, 2022 Invasive aspergillosis remains one of the most devastating fungal diseases and is predominantly linked to infections caused by the opportunistic human mold pathogen Aspergillus fumigatus.
Alcazar-Fuoli, Laura +7 more
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Diagnosis and Treatment of Invasive Aspergillosis Caused by Non-fumigatus Aspergillus spp. [PDF]
, 2023 With increasing frequency, clinical and laboratory-based mycologists are consulted on invasive fungal diseases caused by rare fungal species. This review aims to give an overview of the management of invasive aspergillosis (IA) caused by non-fumigatus ...
Ackermann, Katharina +8 more
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Fungal lung disease encompasses a wide spectrum of organisms and associated clinical conditions, presenting a significant global health challenge. The type and severity of disease are determined by underlying host immunity and infecting fungal strain ...
Agarwal, Ritesh +9 more
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Therapeutic tools for oral candidiasis : current and new antifungal drugs [PDF]
, 2019 Candidiasis is one of the most common opportunistic oral infections that presents different acute and chronic clinical presentations with diverse diagnostic and therapeutic approaches.
Eraso Barrio, Elena +6 more
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The Still Underestimated Problem of Fungal Diseases Worldwide [PDF]
, 2019 In the past few years, fungal diseases caused estimated over 1.6 million deaths annually and over one billion people suffer from severe fungal diseases (Brown et al., 2012; Anonymous, 2017b). Public health surveillance of fungal diseases is generally not
Carolina Coelho +4 more
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Invasive aspergillosis by aspergillus flavus: Epidemiology, diagnosis, antifungal resistance, and management [PDF]
, 2019 Aspergillus flavus is the second most common etiological agent of invasive aspergillosis (IA) after A. fumigatus. However, most literature describes IA in relation to A. fumigatus or together with other Aspergillus species.
Chakrabarti, A. +4 more
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Additional file 1 of Review of the novel antifungal drug olorofim (F901318)
Supplementary Material ...
Vanbiervliet, Yuri +5 more
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Investigation of a Lomentospora prolificans case cluster with whole genome sequencing [PDF]
, 2020 Lomentospora prolificans has caused outbreaks in immunocompromised patients. We performed whole genome sequencing (WGS) on 4 L. prolificans isolates from infections occurring during an 8-month period in the haematology unit at Hospital 1., and 2 isolates
Boan, P. +5 more
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