Results 51 to 60 of about 3,434,663 (291)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Schedule of factors influencing access to psychiatric treatment in persons with schizophrenia: Validity and pilot testing

Indian Journal of Psychological Medicine, 2013
Background : A substantial proportion of patients with severe mental disorders remain untreated in India. Qualitative research has highlighted the complex interplay of multiple factors that preclude schizophrenia patients in rural Indian settings from ...
K Shanivaram Reddy, Jagadisha Thirthalli, C Naveen Kumar, N Krishna Reddy, N R Renukadevi, Vikram Singh Rawat, Jayashree Ramkrishna, Bangalore N Gangadhar   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The relationship among face validity, reliability and predictive validity of university EFL preparatory school achievement tests [PDF]

, 2007
Cataloged from PDF version of article.This study examined the relationship between face validity and relatively more objective measures of tests, such as reliability and predictive validity.
Küçük, Funda
core  

Face Validity for Early Literacy Skills Indicators from Educators’ Perspective [PDF]

The purpose of this study was to determine the face validity of the Early Literacy Skills Indicators (ELSI), which are used to measure the early literacy skills of children aged 3 to 4.
Nur Suhaidah Sukor, Saturia Amiruddin, Adibah Abdul Latif, Ratin Wahyu Juni Atma, Juppri Bacotang, Connie Shin @ Connie Cassy Ompok, Muhamad Suhaimi Taat, Rashidin Idris, Siti Farhana Md. Yasin   +8 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Development and Validation of the Saudi Telehealth Acceptance Scale Based on the Unified Theory of Acceptance and Use of Technology

Saudi Journal of Medicine and Medical Sciences
Background: Telehealth is in early stages in the Kingdom of Saudi Arabia (KSA). Identifying barriers to using telehealth is an essential step prior to its implementation; however, no theoretically based scales exist for the same purpose.
Abdullah A. Almojaibel
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Development and Validation of a Task-Technology Fit Questionnaire to Evaluate Telemedicine Applications From Physicians’ Perspective

IEEE Access
Telemedicine has the potential to enhance both the accessibility and quality of healthcare services. Patients can access telemedicine through various modes, including applications.
Ni Luh Saddhwi Saraswati Adnyani, Rajesri Govindaraju, Khoirul Muslim, Titah Yudhistira   +3 more
doaj   +1 more source