Results 51 to 60 of about 298,885 (252)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Participants’ perspectives on the medical practitioner compassion competency questionnaire

South African Family Practice
Background: The study qualitatively reviewed the Medical Practitioner Compassion Competency Questionnaire (MPCCQ). The revision aimed to extend the questionnaire and address the factor fission found within three subscales of the MPCCQ, namely ...
Willem E. Botha, Michelle Jäckel-Visser, Callie Theron   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Test–Retest Reliability of the Generalized Pain Questionnaire in Patients with Rheumatoid Arthritis and Preliminary Reference Values for Non-Clinical and Several Clinical Samples

Journal of Pain Research, 2023
Niels Jansen,1 Peter M ten Klooster,2 Harald E Vonkeman,3 Jan R Buitenweg1 1Biomedical Signals and Systems, University of Twente, Enschede, the Netherlands; 2Psychology, Health & Technology, University of Twente, Enschede, the Netherlands; 3Department of
Jansen N, ten Klooster PM, Vonkeman HE, Buitenweg JR   +3 more
doaj  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Literature Analysis and Validity Assessment for Animal Models of Attention Deficit and Hyperactive Disorder

Shiyan dongwu yu bijiao yixue
Attention deficit and hyperactive disorder （ADHD） is the most common neurodevelopmental disorder of childhood. It seriously impairs academic achievement， social interaction， and vocational development， and increases the risk of accidental injury and ...
LIAO Wangyue, LEI Shuang, LI Xuan, GUO Min, ZHOU Ruoran   +4 more
doaj   +1 more source

Are Neoclassical Canons Valid for Southern Chinese Faces?

PLoS ONE, 2012
Proportions derived from neoclassical canons, initially described by Renaissance sculptors and painters, are still being employed as aesthetic guidelines during the clinical assessment of the facial morphology.1. to determine the applicability of neoclassical canons for Southern Chinese faces and 2.
Deutsch, CK, McGrath, CPJ, Zwahlen, RA, Jayaratne, YSN   +3 more
openaire   +6 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Comparative Evaluation of Popular Gen-AI Chatbots in Generating Patient Education Material on Pulmonary Artery Catheter Insertion

Annals of Cardiac Anaesthesia
Introduction: Patient education significantly improves outcomes, especially in high-risk procedures. However, traditional educational resources often fail to address patient literacy and emotional needs adequately.
Omshubham Gangadhar Asai, Nayana Sabu, Prakash Gondode, Soumya Das, Gajanan Chauhan   +4 more
doaj   +1 more source