Results 61 to 70 of about 3,434,663 (291)
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Concurrent Validity of the Face Valid Food Security Measure [PDF]
Our objective was to assess the concurrent validity of the face valid food security categorical algorithm with Hawaii residents. We also hypothesized that there would be differences in food security status between ethnic groups.
A. G. Fisher +2 more
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
, 1995 Face validity is a blanket term commonly used by testing and measurement specialists to refer to the layman's judgement of test validity. In the sceptical eyes to experts, the subjective and impressionistic evaluation by the psychometrically untrained ...
Li, Edward Siu-Leung
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Animal models as tools to study the pathophysiology of depression
Brazilian Journal of Psychiatry, 2013 The incidence of depressive illness is high worldwide, and the inadequacy of currently available drug treatments contributes to the significant health burden associated with depression.
Helena M. Abelaira +2 more
doaj +1 more source
, 2022 At the time of the COVID-19 pandemic, face-to-face physical assessment became difficult due to social distancing. In many instances, testing was halted. Remote physical performance testing would circumvent the problem, as did telehealth, which played an ...
Chin Moi Chow, Anju Verma
core +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Participants’ perspectives on the medical practitioner compassion competency questionnaire
South African Family PracticeBackground: The study qualitatively reviewed the Medical Practitioner Compassion Competency Questionnaire (MPCCQ). The revision aimed to extend the questionnaire and address the factor fission found within three subscales of the MPCCQ, namely ...
Willem E. Botha +2 more
doaj +1 more source