Results 61 to 70 of about 298,885 (252)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Journal of Medical Education Development, 2018 Development and assessment of measurement tools are important stages in the research processes regarding social, educational, and medical sciences, which mainly focus on the measurement of characteristics, qualitative variables, and abstract variables ...
Mohammad Masoud Vakili, Nasrin Jahangiri
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A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source
Face adaptation effects show strong and long-lasting transfer from lab to more ecological contexts
Frontiers in Psychology, 2012 A review on recent experiments on figural face aftereffects reveals that adaptation effects in famous faces can be quite sustainable, lasting for hours up to days.
Claus-Christian eCarbon, Thomas eDitye
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Frontiers in Public HealthIntroductionIn many countries, promoting the ability to protect one’s own life and health and to help oneself when faced with adversity is a cornerstone of disaster risk reduction.
Michael Ewers +6 more
doaj +1 more source
ANIMAL MODELS OF POST-TRAUMATIC STRESS DISORDER: FACE VALIDITY
Frontiers in Neuroscience, 2013 Post-traumatic stress disorder (PTSD) is a debilitating condition that develops in a proportion of individuals following a traumatic event. Despite recent advances, ethical limitations associated with human research impede progress in understanding PTSD.
SONAL eGOSWAMI +3 more
doaj +1 more source
TMB Faces Validation Hurdles [PDF]
Cancer Discovery, 2019 Abstract As immune checkpoint inhibitors are approved for more cancers and indications, researchers continue to hunt for biomarkers that can predict which patients will respond to the therapies. One such biomarker, tumor mutation burden, has potential, but requires better standardization across labs and institutions, as well as stronger ...
openaire +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Validity Assessment in the Knowledge & Information Science Researches
Iranian Journal of Information Processing & Management, 2019 The present study has been conducted to evaluate the amount of attention to validity assessment process of research tools, by reviewing the articles published in knowledge & information science journals in Iran over past 10 years.
Khadijeh Shabankareh, Ali Hamidi
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