Results 71 to 80 of about 1,663,728 (298)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Comparative Evaluation of Popular Gen-AI Chatbots in Generating Patient Education Material on Pulmonary Artery Catheter Insertion

Annals of Cardiac Anaesthesia
Introduction: Patient education significantly improves outcomes, especially in high-risk procedures. However, traditional educational resources often fail to address patient literacy and emotional needs adequately.
Omshubham Gangadhar Asai, Nayana Sabu, Prakash Gondode, Soumya Das, Gajanan Chauhan   +4 more
doaj   +1 more source

Animal models as tools to study the pathophysiology of depression

Brazilian Journal of Psychiatry, 2013
The incidence of depressive illness is high worldwide, and the inadequacy of currently available drug treatments contributes to the significant health burden associated with depression.
Helena M. Abelaira, Gislaine Z. Reus, Joao Quevedo   +2 more
doaj   +1 more source

Ethical considerations when carrying out research in one’s own academic institution [PDF]

, 2015
This particular kind of research brings about a series of ethical considerations that may be quite unique to this scenario. One needs to mention the dual role of employee and researcher held by the person carrying out the research.
Caruana, Simon
core  

Towards a tool for the subjective assessment of speech system interfaces (SASSI) [PDF]

, 2000
Applications of speech recognition are now widespread, but user-centred evaluation methods are necessary to ensure their success. Objective evaluation techniques are fairly well established, but previous subjective techniques have been unstructured and ...
Graham, R, Hone, KS
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Assessment of a virtual reality temporal bone surgical simulator: a national face and content validity study

Journal of Otolaryngology - Head and Neck Surgery, 2020
Background Trainees in Otolaryngology–Head and Neck Surgery must gain proficiency in a variety of challenging temporal bone surgical techniques. Traditional teaching has relied on the use of cadavers; however, this method is resource-intensive and does ...
Evan C. Compton, Sumit K. Agrawal, Hanif M. Ladak, Sonny Chan, Monica Hoy, Steven C. Nakoneshny, Lauren Siegel, Joseph C. Dort, Justin T. Lui   +8 more
doaj   +1 more source

Evidence on the Value of Strategic Planning in Marketing: How Much Planning Should a Marketing Planner Plan? [PDF]

What evidence exists on the value of formal planning for strategic decision-making in marketing? This paper reviews the evidence. This includes two tests of face validity.
David J. Reibstein, JS Armstrong
core  

Assessing Face Validity of a Physical Activity Questionnaire for Spanish-Speaking Women in California [PDF]

, 2011
To create a culturally appropriate assessment, the study reported here developed and evaluated the face validity of a visually enhanced Spanish-language physical activity questionnaire. A professional translated the English version of the International
Banna, Jinan C., Keim, Nancy L., Townsend, Marilyn S.   +2 more
core   +3 more sources