Results 81 to 90 of about 3,653,493 (290)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Two-Stage Facial Kinematic Control Strategy for Humanoid Robots Based on Keyframe Detection and Keypoint Cubic Spline Interpolation

Mathematics
A plentiful number of facial expressions is the basis of natural human–robot interaction for high-fidelity humanoid robots. The facial expression imitation of humanoid robots involves the transmission of human facial expression data to servos situated ...
Ye Yuan, Jiahao Li, Qi Yu, Jian Liu, Zongdao Li, Qingdu Li, Na Liu   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

What Happens in Face During a Facial Expression? Using Data Mining Techniques to Analyze Facial Expression Motion Vectors [PDF]

Automatic facial expression recognition is a big challenge in human–computer interaction. Analyzing the changes in the face during a facial expression can be used for this purpose. In this paper, these changes are extracted as a number of motion vectors.
Shoeibi, Afshin, Gorriz, Juan M., Nahavandi, Saeid, Roshanzamir, Mahdi, Roshanzamir, Mohamad, Alizadehsani, Roohallah, Jafari, Mahboobeh, Acharya, U. Rajendra, Khosravi, Abbas   +8 more
core   +1 more source

Video Assessment to Detect Amyotrophic Lateral Sclerosis

Digital Biomarkers
Introduction: Weakened facial movements are early-stage symptoms of amyotrophic lateral sclerosis (ALS). ALS is generally detected based on changes in facial expressions, but large differences between individuals can lead to subjectivity in the diagnosis.
Guilherme Camargo Oliveira, Quoc Cuong Ngo, Leandro Aparecido Passos, Leonardo Silva Oliveira, Stella Stylianou, João Paulo Papa, Dinesh Kumar   +6 more
doaj   +1 more source

Characteristics of facial muscle activity during voluntary facial expressions: Imaging analysis of facial expressions based on myogenic potential data

Neuropsychopharmacology Reports, 2019
Purpose Facial expressions are formed by the coordination of facial muscles and reflect changes in emotion. Nurses observe facial expressions as way of understanding patients. This study conducted basic research using facial myogenic potential topography
Eriko Kuramoto, Saori Yoshinaga, Hiroyuki Nakao, Seiji Nemoto, Yasushi Ishida   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Functional Outcomes of Multiple Sural Nerve Grafts for Facial Nerve Defects after Tumor-Ablative Surgery

Archives of Plastic Surgery, 2015
Background Functional restoration of the facial expression is necessary after facial nerve resection to treat head and neck tumors. This study was conducted to evaluate the functional outcomes of patients who underwent facial nerve cable grafting ...
Myung Chul Lee, Dae Hee Kim, Yeo Reum Jeon, Dong Kyun Rah, Dae Hyun Lew, Eun Chang Choi, Won Jai Lee   +6 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source