We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
The role of lipid metabolism in neuronal senescence
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Morphometric Study of Hypoglossal and Facial Nerves and its Significance in Hypoglossal-Facial Nerve Anastomosis [PDF]
Background: During the repairing of facial nerve injury most common nerve used is the hypoglossal nerve. Aim and Objectives: To measure the distance between the anatomical landmarks, facial nerve and hypoglossal nerve which will be beneficial to ...
Vikram Palimar +2 more
doaj
Acquired ptosis associated with oculomotor and contralateral facial nerve synkinesis: the first reported case [PDF]
Evidence of oculomotor nerve (ON) synkinesis is a common occurrence following both acquired and congenital III nerve palsy. It is generally accepted that aberrant regeneration is the likely aetiology of synkinesis in acquired III nerve palsy, following ...
Conversi, Andrea +7 more
core +2 more sources
Acute HIV Presenting With Unilateral Facial Nerve Paralysis: A Case Report [PDF]
Omar Kandah, Shuo Liu, Peter Montesano
openalex +1 more source
Characteristics of Cerebral Palsy in the Midwestern US
ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim +6 more
wiley +1 more source
Antiviral treatment for Bell's palsy (idiopathic facial paralysis) [PDF]
BACKGROUND: Antiviral agents against herpes simplex virus are widely used in the treatment of idiopathic facial paralysis (Bell's palsy), but their effectiveness is uncertain. Significant morbidity can be associated with severe cases.
Abiko +47 more
core +3 more sources
Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco +18 more
wiley +1 more source
Early Masseter to Facial Nerve Transfer May Improve Smile Excursion in Facial Paralysis
Background:. Masseter-to-facial nerve transfer has been shown to be an effective and safe treatment option in patients with acute and subacute facial palsy.
Shuhao Zhang, MD +4 more
doaj +1 more source
Transcriptome analysis of molecular mechanisms underlying facial nerve injury repair in rats
Although the transcriptional alterations inside the facial nucleus after facial nerve injury have been well studied, the gene expression changes in the facial nerve trunk after injury are still unknown. In this study, we established an adult rat model of
Qian-Qian Cao +6 more
doaj +1 more source

