Results 151 to 160 of about 133,617 (313)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source

Neuromodulation of the central nervous system for facial pain. [PDF]

Neurotherapeutics
Yuen J, Loh A, Darmani G, Sarica C, Patel N, Lozano AM, Hodaie M.   +6 more
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Facial Palsy Accompanied with Herpes Zoster on the Cervical Dermatome ⁣A case report⁣

, 1997
We treated a 56 year old male ailing of painful herpetic eruption on his 2nd, 3rd and 4th left cervical spinal segment. On the 18th day, patient also suffered an abrupt left facial palsy, accompanied with ongoing postherpetic neuralgia even though the ...
윤덕미
core  

Internal Jugular Vein Entrapment: An Underrecognized Cause of Facial Pain. [PDF]

Eur J Neurol
Chan K, Gharib M, Karam J, Won S, Cha YH.   +4 more
europepmc   +1 more source

Microsphere‐Modulated Sensing‐in‐Energy Supercapacitor With Self‐Filtering Ultra‐Large Signal Under High‐g Shocks

Advanced Science, EarlyView.
To overcome severe signal oscillation under extreme impact conditions, this work presents a Sensing‐in‐Energy microdevice which integrates a MEMS inertial structure directly within a supercapacitor electrolyte cavity. Utilizing shock‐driven transient contact and electrolyte damping for signal self‐filtering, it achieves weak‐oscillation, large ...
Zhihao Zheng, Yiqun Wang, Kaiyou Liu, Shancheng Luan, Yajiang Yin, Xiaofeng Wang, Keren Dai, Zheng You   +7 more
wiley   +1 more source

Editorial: Oro-facial pain: pathophysiology, molecular mechanisms, diagnostic innovations and multidisciplinary management. [PDF]

Front Oral Health
Jayasinghe RD, Jayasinghe RM, Leuke Bandra D, Kanmodi KK.   +3 more
europepmc   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Comment on "Diagnosis and management of persistent idiopathic facial pain following dental procedures: a retrospective study". [PDF]

J Korean Assoc Oral Maxillofac Surg
Cherukunnummal S.
europepmc   +1 more source