Results 121 to 130 of about 274,220 (302)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Barriers and facilitators of community-based nursing development: A scoping review

Journal of Education and Health Promotion
In the last few decades, chronic diseases have spread and new and emerging health and social issues have affected people’s health. COVID-19 and other emerging and re-emerging diseases are creating new challenges for societies that affect how healthcare ...
Naiemeh Seyedfatemi, Hamid Peyrovi, Salime Goharinezhad, Saeid Hossein Oghli   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Barriers and Facilitators to Health-Care Provider Payment Reform – A Scoping Literature Review

, 2023
Costase Ndayishimiye,1,2 Marzena Tambor,2 Katarzyna Dubas-Jakóbczyk2 1Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, Krakow, Poland; 2Health Economics and Social Security Department, Institute of Public Health ...
Ndayishimiye C, Tambor M, Dubas-Jakóbczyk K   +2 more
core  

‘Motivating Implicit Chinese to Express Themselves Is the Biggest Barrier’: A Qualitative Study of Chinese Researchers' Perceptions of Barriers and Facilitators to Patient Engagement in Research

Health Expectations
Background Patient Engagement in Research (PER) has demonstrated benefits for patients, researchers and research outcomes. However, China lacks substantial experience in implementing PER.
Lin Yang, Yu‐xiao Liu, Bi‐xia Wang, Meng‐jiao Yu, Wei‐Wei Bian, Cai‐feng Wang, Hong Ruan   +6 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Exploring barriers and facilitators to effective self-management in individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: an Interpretative Phenomenological Analysis [PDF]

The present study explored the lived experiences of individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome to identify barriers and facilitators to effective self-management.
Roberts, M., Gaffiero, D.
core   +1 more source