Results 141 to 150 of about 220,539 (317)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Facilitators and barriers to hypertension self-management in urban African Americans: perspectives of patients and family members

, 2013
Sarah J Flynn,1,2 Jessica M Ameling,1,2 Felicia Hill-Briggs,1–3 Jennifer L Wolff,4,5 Lee R Bone,1,3 David M Levine,1,4 Debra L Roter,3 LaPricia Lewis-Boyer,1,2 Annette R Fisher,6 Leon Purnell,6 Patti L Ephraim,2,7 Jeffrey Barbers,1,2 Stephanie L ...
Bone LR, Ramamurthi HC, Flynn SJ, Martin D, Boulware LE, Roter DL, Fitzpatrick SL, Ephraim PL, Albert MC, Fisher AR, Levine DM, Purnell L, Cooper LA, Fagan PJ, Lewis-Boyer L, Barbers J, Ameling JM, Hill-Briggs F, Wolff JL   +18 more
core  

Barriers and facilitators for the implementation and expansion of outpatient parenteral antimicrobial therapy: a systematic review

Outpatient parenteral antimicrobial therapy (OPAT) has been expanding in recent years and serves as a viable solution in reducing the shortage of hospital beds. However, the wider implementation of OPAT faces numerous challenges.
Cotta, MO, Assefa, GM, Sime, F, Erku, D, Mohammed, SA   +4 more
core   +1 more source

Facilitating reproducibility [PDF]

Nature Chemical Biology, 2013
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Facilitators and barriers to doctoral supervision: A case study in health sciences

, 2016
Supervision capacity is becoming an issue that may restrict the ability of universities to meet eligible students’ needs. Although there has been considerable research into the methods of supervision and the supervisor-student relationship, at this time ...
Callaghan, Kathleen, McCormick, Ross, Askew, Catherine, Dixon, Robyn, Wang, Grace Ying, Shulruf, Boaz   +5 more
core  

Barriers and Facilitators to Adherence to Exercise-Based Cardiac Rehabilitation Among Coronary Artery Disease Patients: A Scoping Review

Journal of Multidisciplinary Healthcare
Xinqi Zhao,1,* Shi Zhang,2,* Fan Zhang,2 Xinyu Wu,1 Zhe Zhang,1 Yue Liu,2 Junwen Jiang,2 Zheng Li,2 Siqi Li,2 Sicheng Zheng,2 Xiao Yang,3 Xing Ju,1 Hang Li,4 Lihong Gong,2 DeZhao Kong2,5,6 1Liaoning University of Traditional Chinese ...
Zhao X, Zhang S, Zhang F, Wu X, Zhang Z, Liu Y, Jiang J, Li Z, Li S, Zheng S, Yang X, Ju X, Li H, Gong L, Kong D   +14 more
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source