Results 41 to 50 of about 97,962 (296)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Development of an Easy-to-Use Tool for the Assessment of Emergency Department Physical Design
Emergency, 2014 Physical design of the emergency department (ED) has an important effect on its role and function. To date, no guidelines have been introduced to set the standards for the construction of EDs in Iran.
Alireza Majidi +4 more
doaj
Modernization of the competencies of construction managers in the implementation of projects using BIM [PDF]
BIO Web of ConferencesThe use of Building Information Modeling at the construction stage of the facility involves not only the use of new technologies, but also the revision of the functional roles of participants in the implementation of the investment and construction ...
Zharov Iaroslav V.
doaj +1 more source
A conceptual framework for multi-modal interactive virtual workspace [PDF]
, 2001 Construction projects involve a large number of both direct stakeholders (clients, professional teams, contractors, etc.) and indirect stakeholders (local authorities, residents, workers, etc.).
Gobbetti, E +13 more
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Nuclear Engineering and Technology, 2023 The STELLA-2 is a large-scale sodium thermal-hydraulic integral effect test facility and supports the development of PGSFR. The facility adopted Pump Simulation Loop System (PSLS) concept for the mechanical sodium pump in the reference reactor to control
Jung Yoon +4 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
, 2023 This healthcare co-design project supported the spatial and service design of a new residential eating disorders (ED) facility at a major metropolitan hospital in Melbourne, Australia.
O'Kane, C. +13 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source