Results 41 to 50 of about 82,917 (311)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A conceptual framework for multi-modal interactive virtual workspace [PDF]

, 2001
Construction projects involve a large number of both direct stakeholders (clients, professional teams, contractors, etc.) and indirect stakeholders (local authorities, residents, workers, etc.).
Gobbetti, E, Marache, M, Marache, Mathieu, Da Dalto, Laurent, Aspin, Rob, Aspin, R, Fernando, T, Fernando, Terrence, Shelbourn, M, Shelbourn, Mark, DaDalto, L, Gobbetti, Enrico, Soubra, Souheil, Soubra, S   +13 more
core  

Modernization of the competencies of construction managers in the implementation of projects using BIM [PDF]

BIO Web of Conferences
The use of Building Information Modeling at the construction stage of the facility involves not only the use of new technologies, but also the revision of the functional roles of participants in the implementation of the investment and construction ...
Zharov Iaroslav V.
doaj   +1 more source

Similarity evaluation of the pump simulation loop in STELLA-2 for conservation of mechanical sodium pump characteristics

Nuclear Engineering and Technology, 2023
The STELLA-2 is a large-scale sodium thermal-hydraulic integral effect test facility and supports the development of PGSFR. The facility adopted Pump Simulation Loop System (PSLS) concept for the mechanical sodium pump in the reference reactor to control
Jung Yoon, Jewhan Lee, Jaehyuk Eoh, Hyungmo Kim, Dong Eok Kim   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Development of an Easy-to-Use Tool for the Assessment of Emergency Department Physical Design

Emergency, 2014
Physical design of the emergency department (ED) has an important effect on its role and function. To date, no guidelines have been introduced to set the standards for the construction of EDs in Iran.
Alireza Majidi, Ali Tabatabaey, Hassan Motamed, Maryam Motamedi, Mohammad Mehdi Forouzanfar   +4 more
doaj  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

BIM‐Based Urban Building Facility Information Management System

Engineering Reports
Traditional facility management in the construction industry faces critical challenges, including fragmented lifecycle data, inefficient manual operations, and disconnection between design, construction, and operation phases, which severely hinder data ...
Cheng Guo, Yang Ding, Zhen‐Zhen Guo, Shuang‐Xi Zhou, Tian‐Yun Chu   +4 more
doaj   +1 more source