Results 61 to 70 of about 82,917 (311)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The Little Legon Mushroom Farm: Building Around Nature, Feeding Households, and Demonstrating a Replicable Model for Backyard Agro-Enterprise in Ghana [PDF]

Journal of Agriculture and Rural Development Studies
This article documents the design, construction, cost, and productive performance of the Little Legon Mushroom (LLM) Farm, a small-scale oyster mushroom (Pleurotus ostreatus) growing facility established in Little Legon, Greater Accra, Ghana.
Yegandi Imhotep Paul Alagidede
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Exit Statement : 2001-2009 CRC for Construction Innovation

, 2009
The Cooperative Research Centre (CRC) for Construction Innovation is Australia’s national centre for research and innovation focused on the needs of the property, design, construction and facility management sectors. The period covered by this report is

core  

Design status of the Vacuum Vessel of DTT facility

, 2021
The Divertor Tokamak Test (DTT) facility is an experimental facility under design and construction at ENEA C.R. Frascati. The aim of DTT is to investigate the power exhaust problem in a tokamak, providing possible alternative divertor solutions, with ...
Ramogida G., Polli G. M., Roccella S., Giorgetti F., Barone G., Martelli E., Lombroni R.   +6 more
core   +1 more source

Application of importance-satisfaction analysis and influence-relations map to evaluate design delay factors

Journal of Civil Engineering and Management, 2014
Design delays can negatively influence the total completion time of a facility construction project. Knowing the factors to which design delays are most sensitive supports the time management of designs.
Wei-Chih Wang, Chia-Li Lin, Shih-Hsu Wang, Jang-Jeng Liu, Ming-Tsung Lee   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PACTEL and PWR PACTEL Test Facilities for Versatile LWR Applications

Science and Technology of Nuclear Installations, 2012
This paper describes construction and experimental research activities with two test facilities, PACTEL and PWR PACTEL. The PACTEL facility, comprising of reactor pressure vessel parts, three loops with horizontal steam generators, a pressurizer, and ...
Virpi Kouhia, Heikki Purhonen, Vesa Riikonen, Markku Puustinen, Riitta Kyrki-Rajamäki, Juhani Vihavainen   +5 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source