Results 51 to 60 of about 97,962 (296)

BIM‐Based Urban Building Facility Information Management System

Engineering Reports
Traditional facility management in the construction industry faces critical challenges, including fragmented lifecycle data, inefficient manual operations, and disconnection between design, construction, and operation phases, which severely hinder data ...
Cheng Guo, Yang Ding, Zhen‐Zhen Guo, Shuang‐Xi Zhou, Tian‐Yun Chu   +4 more
doaj   +1 more source

Community-Based Design as an Integrated Process for Public Facility Development in Subsidized Housing: A Case Study of Cluster Olena 6, Alam Sanggar Indah Residence, West Bandung Regency

Emara: Indonesian Journal of Architecture
Public facilities are essential for supporting social interaction and improving the quality of residential environments. However, in some subsidized housing developments, public facilities are often provided as undeveloped land without specific ...
Oktavi Elok Hapsari, Oki Tri Harmawan
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cloud interaction technologies in the design and construction

MATEC Web of Conferences, 2018
One of the problems that can arise in the way of successful implementation of construction projects is the separation and inadequate interaction between the participants in the process in the design and construction of the facility.
Garyaev Nikolay, Rybakova Angelina
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Incorporating knowledge of construction and facility management into the design in the BIM environment [PDF]

, 2018
Many studies have highlighted the importance of early project phases, during which the levels of uncertainty and stakeholder influence are considerably high, but the cost of change is substantially low.
McGetrick, Patrick, Meng, Xianhai, Wang, Hao   +2 more
core   +4 more sources

Corrosion behaviour of steel rebars embedded in a concrete designed for the construction of an intermediate-level radioactive waste disposal facility

EPJ Web of Conferences, 2013
The National Atomic Energy Commission of the Argentine Republic is developing a nuclear waste disposal management programme that contemplates the design and construction of a facility for the final disposal of intermediate-level radioactive wastes.
Schulz F.M., Arva E.A., Duffó G.S., Vazquez D.R.   +3 more
doaj   +1 more source

An Approach to the Commercial Production of Highly Active Pharmaceutical Ingredients

CHIMIA, 2016
To meet the requirements for production of highly active pharmaceutical ingredients (API) new approaches and technical solutions are required. Prior to the design and construction of a new multipurpose manufacturing facility, a process study was
Andreas Beyeler, Roland Wilhelm, Bernd Brodbeck   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source