Results 81 to 90 of about 710,173 (345)

The other GMP: good manufacturing practice and its importance in the validation of constructed pharmaceutical facilities [PDF]

, 2005
The work reported is part of an ongoing PhD study prompted by the particular difficulties encountered when two very different quality cultures interact (in this case Pharmaceutical industry clients and Construction industry providers).
Edge, Jerry, Greenwood, David, Render, Neil   +2 more
core  

Design and Manufacture of the RF Power Supply and RF Transmission Line for SANAEM Project Prometheus

, 2017
A 1-5 MeV proton beamline is being built by the Turkish Atomic Energy Authority in collaboration with a number of graduate students from different universities.
Ahiska, F., Alacakir, A., Cicek, E., Kilic, I., Ogur, S., Ozbey, A., Turemen, G., Unel, G., Yasatekin, B.   +8 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Satellite remote sensing facility for oceanograhic applications [PDF]

The project organization, design process, and construction of a Remote Sensing Facility at Scripps Institution of Oceanography at LaJolla, California are described.
Evans, R. H., Kent, S. S., Seidman, J. B.   +2 more
core   +1 more source

Development of a thermal ionizer as ion catcher

, 2008
An effective ion catcher is an important part of a radioactive beam facility that is based on in-flight production. The catcher stops fast radioactive products and emits them as singly charged slow ions.
A. Rogachevskiy, A.J. Mol, Bayat, Berg, C.J.G. Onderwater, Clifford, Crank, Datz, Dendooven, E. Traykov, Fick, Fujioka, H.W. Wilschut, Huyse, Jungmann, Jungmann, K. Jungmann, Kirchner, Kirchner, Kirchner, L. Huisman, L. Willmann, Langmuir, Love, M. da Silva e Silva, M. Sohani, McCracken, O. Versolato, O.C. Dermois, Rossbach, S. De, Traykov, U. Dammalapati, W. Kruithof, Willmann, Wilschut, Ziegler, Ärje   +37 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Placial Justice: Restoring Rehabilitation and Correctional Legitimacy Through Architectural Design

SAGE Open, 2020
Efforts to reduce the correction population have taken many forms across the United States, with the redesign of correctional edifices being met with mixed support from stakeholders.
Victor J. St. John
doaj   +1 more source

Deep Underground Science and Engineering Laboratory - Preliminary Design Report

, 2011
The DUSEL Project has produced the Preliminary Design of the Deep Underground Science and Engineering Laboratory (DUSEL) at the rehabilitated former Homestake mine in South Dakota.
Acheson, Steven, Alonso, Jose, Bauer, Paul, Chan, Yuen-Dat, Chinowsky, William, Dangermond, Steve, De Vries, Syd, Detwiler, Jason A., DiGennaro, Richard, Exter, Elizabeth, Fernandez, Felix B., Freer, Elizabeth L., Gilchriese, Murdock G. D., Goldschmidt, Azriel, Grammann, Ben, Griffing, William, Harlan, Bill, Haxton, Wick C., Headley, Michael, Heise, Jaret, Hladysz, Zbigniew, Jacobs, Dianna, Johnson, Michael, Kadel, Richard, Kaufman, Robert, King, Greg, Lanou, Robert, Lemut, Alberto, Lesko, Kevin T., Ligeti, Zoltan, Marks, Steve, Martin, Ryan D., Matthesen, John, Matthew, Brendan, Matthews, Warren, McConnell, Randall, McElroy, William, Meyer, Deborah, Norris, Margaret, Plate, David, Robinson, Kem E., Roggenthen, William, Salve, Rohit, Sayler, Ben, Scheetz, John, Tarpinian, Jim, Taylor, David, Vardiman, David, Wheeler, Ron, Willhite, Joshua, Yeck, James   +50 more
core  

Prevention through design: Trade-offs in reducing occupational health and safety risk for the construction and operation of a facility [PDF]

, 2013
Purpose - The research aims to explore the interaction between design decisions that reduce occupational health and safety (OHS) risk in the operation stage of a facility's life cycle and the OHS experiences of workers in the construction stage ...
Blismas, N, Cooke, T, Lingard, H, Wakefield, R   +3 more
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source