Results 51 to 60 of about 1,258,397 (284)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

A Survey of Approximation Algorithms for the Universal Facility Location Problem

Mathematics
The facility location problem is a classical combinatorial optimization problem with extensive applications spanning communication technology, economic management, traffic governance, and public services.
Hanyin Xiao, Jiaming Zhang, Zhikang Zhang, Weidong Li   +3 more
doaj   +1 more source

Super-Fast Distributed Algorithms for Metric Facility Location [PDF]

, 2013
This paper presents a distributed O(1)-approximation algorithm, with expected-$O(\log \log n)$ running time, in the $\mathcal{CONGEST}$ model for the metric facility location problem on a size-$n$ clique network.
Berns, Andrew, Hegeman, James, Pemmaraju, Sriram V.   +2 more
core  

A simple dual ascent algorithm for the multilevel facility location problem [PDF]

, 2001
We present a simple dual ascent method for the multilevel facility location problem which finds a solution within $6$ times the optimum for the uncapacitated case and within $12$ times the optimum for the capacitated one.
Bumb, A.F., Kern, W.
core   +4 more sources

Facility Location on Terrains [PDF]

, 1998
Given a terrain defined as a piecewise-linear function with n triangles, and m point sites on it, we would like to identify the location on the terrain that minimizes the maximum distance to the sites. The distance is measured as the length of the Euclidean shortest path along the terrain. To simplify the problem somewhat, we extend the terrain to (the
Aronov, B., Kreveld, M.J. van, Oostrum, R. van, Varadarajan, Kasturirangan   +3 more
openaire   +6 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Optimal Location of an Oil Storage Facility

Undergraduate Journal of Mathematical Modeling: One + Two, 2010
Given three oil drilling sites, we devise a method to determine the optimal location for a storage facility such that the total length of pipeline required to connect each site to the facility is minimized. First we represent the total distance of piping
Giovanni Quiel
doaj   +1 more source

Red–Blue k-Center Clustering with Distance Constraints

Mathematics, 2023
We consider a variant of the k-center clustering problem in IRd, where the centers can be divided into two subsets—one, the red centers of size p, and the other, the blue centers of size q, such that p+q=k, and each red center and each blue center must ...
Marzieh Eskandari, Bhavika B. Khare, Nirman Kumar, Bahram Sadeghi Bigham   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A simulation based research on chance constrained programming in robust facility location problem

Open Physics, 2017
Since facility location decisions problem include long-term character and potential parameter variations, it is important to consider uncertainty in its modeling.
Kaijun Leng, Wen Shi, Guanghua Song, Lin Pan   +3 more
doaj   +1 more source