Results 61 to 70 of about 4,534,692 (327)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A Survey of Approximation Algorithms for the Universal Facility Location Problem

Mathematics
The facility location problem is a classical combinatorial optimization problem with extensive applications spanning communication technology, economic management, traffic governance, and public services.
Hanyin Xiao, Jiaming Zhang, Zhikang Zhang, Weidong Li   +3 more
doaj   +1 more source

Coordination of Mobile Mules via Facility Location Strategies

, 2017
In this paper, we study the problem of wireless sensor network (WSN) maintenance using mobile entities called mules. The mules are deployed in the area of the WSN in such a way that would minimize the time it takes them to reach a failed sensor and fix ...
A Farinelli, A Krause, B Gerkey, C ReVelle, J Crowcroft, J Munkres, L Levin, M Charikar, M Tambe, MD Francesco, MS Manasse, MS Maxwell, NH Mustafa, O Kariv, O Kariv, O Tedas, O Urra, R Zivan, RC Shah, S Anand, S Konur, T Rui, TF Gonzalez, V Arya, V Milyeykovski, Y Wang   +25 more
core   +1 more source

Strategy-Proof Facility Location for Concave Cost Functions [PDF]

, 2013
We consider k-Facility Location games, where n strategic agents report their locations on the real line, and a mechanism maps them to k facilities.
Fotakis, Dimitris, Tzamos, Christos
core   +1 more source

Facility Location on Terrains [PDF]

, 1998
Given a terrain defined as a piecewise-linear function with n triangles, and m point sites on it, we would like to identify the location on the terrain that minimizes the maximum distance to the sites. The distance is measured as the length of the Euclidean shortest path along the terrain. To simplify the problem somewhat, we extend the terrain to (the
Aronov, B., Kreveld, M.J. van, Oostrum, R. van, Varadarajan, Kasturirangan   +3 more
openaire   +6 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Optimal Location of an Oil Storage Facility

Undergraduate Journal of Mathematical Modeling: One + Two, 2010
Given three oil drilling sites, we devise a method to determine the optimal location for a storage facility such that the total length of pipeline required to connect each site to the facility is minimized. First we represent the total distance of piping
Giovanni Quiel
doaj   +1 more source

Super-Fast Distributed Algorithms for Metric Facility Location [PDF]

, 2013
This paper presents a distributed O(1)-approximation algorithm, with expected-$O(\log \log n)$ running time, in the $\mathcal{CONGEST}$ model for the metric facility location problem on a size-$n$ clique network.
Berns, Andrew, Hegeman, James, Pemmaraju, Sriram V.   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A simulation based research on chance constrained programming in robust facility location problem

Open Physics, 2017
Since facility location decisions problem include long-term character and potential parameter variations, it is important to consider uncertainty in its modeling.
Kaijun Leng, Wen Shi, Guanghua Song, Lin Pan   +3 more
doaj   +1 more source