Results 51 to 60 of about 4,534,692 (327)

Parallel Optimization Algorithm for Competitive Facility Location

open access: yesMathematical Modelling and Analysis, 2015
A stochastic search optimization algorithm is developed and applied to solve a bi-objective competitive facility location problem for firm expansion.
Algirdas Lančinskas   +2 more
doaj   +1 more source

Locating a bioenergy facility using a hybrid optimization method [PDF]

open access: yes, 2010
In this paper, the optimum location of a bioenergy generation facility for district energy applications is sought. A bioenergy facility usually belongs to a wider system, therefore a holistic approach is adopted to define the location that optimizes the ...
Rentizelas, Athanasios A.   +1 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel   +3 more
wiley   +1 more source

A Dynamic Framework for Community-Facility Siting with Inter-Community Competition

open access: yesApplied Sciences
Locating community facilities is a long-term, daunting task for governments, requiring ongoing budget or policy updates for gradual improvement. This study proposes a bi-objective multi-scenario dynamic model (BOMSDM) for community-facility siting, which
Sisi Zhu, Haoying Han, Anran Dai
doaj   +1 more source

Scalable Facility Location for Massive Graphs on Pregel-like Systems [PDF]

open access: yes, 2015
We propose a new scalable algorithm for facility location. Facility location is a classic problem, where the goal is to select a subset of facilities to open, from a set of candidate facilities F , in order to serve a set of clients C.
Aristides Gionis   +4 more
core   +1 more source

Predicting Optimal Facility Location without Customer Locations [PDF]

open access: yesProceedings of the 23rd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, 2017
Deriving meaningful insights from location data helps businesses make better decisions. One critical decision made by a business is choosing a location for its new facility. Optimal location queries ask for a location to build a new facility that optimizes an objective function.
Yilmaz, Emre   +2 more
openaire   +3 more sources

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu   +8 more
wiley   +1 more source

OR models in urban service facility location: A critical review of applications and future developments

open access: yesEuropean Journal of Operational Research, 2019
Facility location models are well established in various application areas with more than a century of history in academia. Since the 1970s the trend has been shifting from manufacturing to service industries.
R. Farahani   +4 more
semanticscholar   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee   +9 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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