Results 51 to 60 of about 2,658 (212)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola +4 more
wiley +1 more source
Robust Facility Location Problem for Bio-waste Transportation
Chemical Engineering Transactions, 2017 The article presents an optimisation tool for bio-waste facility allocation. The quantity of bio-waste produced in individual territorial units is a key factor for the selection of localities when constructing a new facility. Bio-waste production changes
D. Hrabec +5 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
A simulation based research on chance constrained programming in robust facility location problem
Open Physics, 2017 Since facility location decisions problem include long-term character and potential parameter variations, it is important to consider uncertainty in its modeling.
Kaijun Leng +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Undesirable Facility Location under Uncertainty: Modeling and Algorithm [PDF]
مدیریت تولید و عملیات, 2019 : In undesirable facility location problem contrary to desirable location, facilities are located far from service receiver facilities as much as possible. The problem of locating such facilities is discussed in this study.
Parisima Pakravan, Javad Behnamian
doaj +1 more source
, 2022 The location of the production, distribution and storage facilities of organizations, remains one of the most important strategic decision production and operations managers have to make. Minimizing total cost and distance traveled is the fundamental objective in deciding the location of facilities in order to maximize total profit.
Nneoma Benita Amos, Edafe Bawa Dogo
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source