Results 81 to 90 of about 3,593,801 (351)

A New Local Search for Continuous Location Problems [PDF]

, 2013
This paper presents a new local search approach for solving continuous location problems. The main idea is to exploit the relation between the continuous model and its discrete counterpart.
Mladenovic, Nenad, Drezner, Zvi, Brimberg, Jack, Salhi, Said   +3 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

A Facility Location-Allocation Model for Determining Number of Depot to Distribute Material in the Rattan Furniture Industry by Considering Dynamic Demand [PDF]

, 2010
This paper is a study of a facility location-allocation problem in the rattan furniture industry. There are six production centers (PCs) of rattan furniture in Surakarta and its surroundings.
Yuniaristanto,, Sutopo, Wahyudi, Andreadi, Puput Wahyu, Aisyati, Azizah   +3 more
core  

Heuristics for a continuous multi-facility location problem with demand regions

, 2015
We propose mathematical programming formulations of the single and multiple facility versions of the problem considered. The single facility location problem is formulated as a second order cone programming (SOCP) problem, and hence is solvable in ...
Tural, Mustafa Kemal, İyigün, Cem, Dinler, Derya   +2 more
core   +1 more source

A New Type of Chronic Wound Infection after Wisdom Tooth Extraction: A Diagnostic Approach with 16S-rRNA Gene Analysis, Next-Generation Sequencing, and Bioinformatics

Pathogens, 2020
Delayed-onset infections are rare postoperative complications of lower third molar extractions. This article presents a case of a chronic combined hard and soft tissue infection after the extraction of a third molar, where the causative organisms could ...
Sebastian Böttger, Silke Zechel-Gran, Philipp Streckbein, Michael Knitschke, Torsten Hain, Markus Weigel, Jan-Falco Wilbrand, Eugen Domann, Hans-Peter Howaldt, Sameh Attia   +9 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Genetic markers of late radiation toxicity in the era of image-guided radiotherapy: lower toxicity rates reduce the predictive value of γ-H2AX foci decay ratio in patients undergoing pelvic radiotherapy

Radiation Oncology
Background A predictive assay for late radiation toxicity would allow more personalized treatment planning, reducing the burden of toxicity for the more sensitive minority, and improving the therapeutic index for the majority.
Anna C. Nuijens, Arlene L. Oei, Lisa Koster, Ron A. Hoebe, Nicolaas A.P. Franken, Coen R.N. Rasch, Lukas J.A. Stalpers   +6 more
doaj   +1 more source

Clustering based hybrid approach for facility location problem [PDF]

Management Science Letters, 2017
The main objective of facility location problem is the utilization of the facility by maximum number of possible customers so that the profit is maximized.
Ashish Sharma, Ashish Sharma, A. S. Jalal   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source