Results 81 to 90 of about 4,534,692 (327)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
On a class of intersection graphs [PDF]
, 2013 Given a directed graph D = (V,A) we define its intersection graph I(D) = (A,E) to be the graph having A as a node-set and two nodes of I(D) are adjacent if their corresponding arcs share a common node that is the tail of at least one of these arcs.
Baïou, Mourad +3 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Radiation OncologyBackground A predictive assay for late radiation toxicity would allow more personalized treatment planning, reducing the burden of toxicity for the more sensitive minority, and improving the therapeutic index for the majority.
Anna C. Nuijens +6 more
doaj +1 more source
A Facility Location-Allocation Model for Determining Number of Depot to Distribute Material in the Rattan Furniture Industry by Considering Dynamic Demand [PDF]
, 2010 This paper is a study of a facility location-allocation problem in the rattan furniture industry. There are six production centers (PCs) of rattan furniture in Surakarta and its surroundings.
Aisyati, Azizah +3 more
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Hierarchical Facility Location Model for allocating cancer treatment units in interior of Rio de Janeiro [PDF]
Production, 2019 Paper aims This work aims at proposing a mathematical model for allocation of oncological treatment units of SUS. Originality A model of the same architecture was not found in the literature for the delimited problem.
Isabella Fischer Guindani Vieira +2 more
doaj +1 more source
From Recommendation Systems to Facility Location Games
, 2018 Recommendation systems are extremely popular tools for matching users and contents. However, when content providers are strategic, the basic principle of matching users to the closest content, where both users and contents are modeled as points in some ...
Ben-Porat, Omer +3 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Bioethanol facility location selection using best-worst method
Applied Energy, 2019 One of the major factors in the success of renewable energy is finding a proper location for production facilities. At a national level, different parts of a country (e.g.
Siamak Kheybari, M. Kazemi, J. Rezaei
semanticscholar +1 more source