Results 91 to 100 of about 3,593,801 (351)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Boolean facility location problem with client preferences
Науковий вісник Ужгородського університету. Серія: Математика і інформатика, 2018 Boolean facility location problem with client preferences is considered. Mathematical model of the problem is built. Branchs and bounds method to solve the problem is proposed. The lower bound calculation method as the solution of the linear programming
Ю. В. Андрашко +1 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
A Tabu Search Heuristic Procedure for the Capacitated Facility Location Problem [PDF]
A tabu search heuristic procedure for the capacitated facility location problem is developed, implemented and computationally tested. The heuristic procedure uses both short term and long term memories to perform the main search process as well as the ...
Minghe Sun
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Bioethanol facility location selection using best-worst method
Applied Energy, 2019 One of the major factors in the success of renewable energy is finding a proper location for production facilities. At a national level, different parts of a country (e.g.
Siamak Kheybari, M. Kazemi, J. Rezaei
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2022 The location of the production, distribution and storage facilities of organizations, remains one of the most important strategic decision production and operations managers have to make. Minimizing total cost and distance traveled is the fundamental objective in deciding the location of facilities in order to maximize total profit.
Nneoma Benita Amos, Edafe Bawa Dogo
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Devising a Corporate Facility Location Strategy to Maximize Shareholder Wealth [PDF]
Location decisions should consider all related impacts upon a firm’s shareholder wealth. Overall, firm cost savings available at alternative locations need to be carefully examined in addition to a location’s impact on corporate sales revenues.
Mauricio Rodriguez +2 more
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