Results 111 to 120 of about 3,593,801 (351)
Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes
iScienceSummary: Complex lipid metabolism plays a crucial role in regulating aging. We recently discovered that the phospholipid bis(monoacylglycero)phosphate (BMP) increases in aged human muscles and many mouse tissues.
Sanne van der Rijt +12 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
The distortion of distributed facility location
Artificial IntelligencezbMATH Open Web Interface contents unavailable due to conflicting licenses.
Aris Filos-Ratsikas +3 more
openaire +3 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The capacitated mobile facility location problem
European Journal of Operational Research, 2019 The capacitated mobile facility location problem (CMFLP) arises in logistics planning of community outreach programs delivered via mobile facilities. It adds capacity restrictions to the mobile facility location problem introduced previously by Demaine ...
S. Raghavan, M. Sahin, F. Salman
semanticscholar +1 more source
Intertemporal and Spatial Location of Disposal Facilities [PDF]
The optimal capacity and location of a sequence of landfills are studied, and the interactions between both decisions are pointed out. Deciding the capacity of a landfill has some spatial implications, because it effects the feasible region for the rest ...
Francisco J. André +2 more
core +2 more sources
AHP Methodology Application in Garage-parking Facility Location Selection
Promet (Zagreb), 2011 The paper deals with the selection of traffic infrastructure facility location by applying the AHP (Analytic Hierarchy Process) multi-criteria analysis methodology.
Aleksandra Deluka-Tibljaš +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
An Exponential Neighborhood Local Search Algorithm for the Single Row Facility Location Problem [PDF]
In this work we present a local search algorithm for the single row facility location problem. In contrast to other local search algorithms for the problem, our algorithm uses an exponential neighborhood structure.
Ghosh, Diptesh
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source