Results 1 to 10 of about 9,032 (149)

Cardiac Acetylation in Metabolic Diseases

Biomedicines, 2022
Lysine acetylation is a highly conserved mechanism that affects several biological processes such as cell growth, metabolism, enzymatic activity, subcellular localization of proteins, gene transcription or chromatin structure.
Emilie Dubois-Deruy, Yara El Masri, Annie Turkieh, Philippe Amouyel, Florence Pinet, Jean-Sébastien Annicotte   +5 more
doaj   +1 more source

Sepsis-like Energy Deficit Is Not Sufficient to Induce Early Muscle Fiber Atrophy and Mitochondrial Dysfunction in a Murine Sepsis Model

Biology, 2023
Sepsis-induced myopathy is characterized by muscle fiber atrophy, mitochondrial dysfunction, and worsened outcomes. Whether whole-body energy deficit participates in the early alteration of skeletal muscle metabolism has never been investigated.
Alexandre Pierre, Claire Bourel, Raphael Favory, Benoit Brassart, Frederic Wallet, Frederic N. Daussin, Sylvain Normandin, Michael Howsam, Raphael Romien, Jeremy Lemaire, Gaelle Grolaux, Arthur Durand, Marie Frimat, Bruno Bastide, Philippe Amouyel, Eric Boulanger, Sebastien Preau, Steve Lancel   +17 more
doaj   +1 more source

Desmin aggrephagy in rat and human ischemic heart failure through PKCζ and GSK3β as upstream signaling pathways

Cell Death Discovery, 2021
Post-translational modifications of cardiac proteins could participate to left contractile dysfunction resulting in heart failure. Using a rat model of ischemic heart failure, we showed an accumulation of phosphorylated desmin leading to toxic aggregates
Marion Bouvet, Emilie Dubois-Deruy, Annie Turkieh, Paul Mulder, Victoriane Peugnet, Maggy Chwastyniak, Olivia Beseme, Arthur Dechaumes, Philippe Amouyel, Vincent Richard, Nicolas Lamblin, Florence Pinet   +11 more
doaj   +1 more source

Mitophagy Regulation Following Myocardial Infarction

Cells, 2022
Mitophagy, which mediates the selective elimination of dysfunctional mitochondria, is essential for cardiac homeostasis. Mitophagy is regulated mainly by PTEN-induced putative kinase protein-1 (PINK1)/parkin pathway but also by FUN14 domain-containing 1 (
Annie Turkieh, Yara El Masri, Florence Pinet, Emilie Dubois-Deruy   +3 more
doaj   +1 more source

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

Acta Neuropathologica Communications, 2022
The Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer’s disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms.
Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis, Nicolas Barois, Fabien Delahaye, Bart Dermaut, Jean-Charles Lambert, Marcos R. Costa, Pierre Dourlen   +21 more
doaj   +1 more source

Identification of several eating habits that mediate the association between eating behaviors and the risk of obesity

Obesity Science & Practice, 2022
Objective Eating behaviors play important roles in the development of obesity. A better knowledge of the psychological aspects of eating behaviors in individuals with and without obesity and their consequences on daily eating and lifestyle habits would ...
Estelle Aymes, Gabrielle Lisembard, Jean Dallongeville, Julien Rousseaux, Marie‐Pierre Dumont, Philippe Amouyel, Monique Romon, Aline Meirhaeghe   +7 more
doaj   +1 more source

Identification of patient subtypes based on protein expression for prediction of heart failure after myocardial infarction

iScience, 2023
Summary: This study investigates the ability of high-throughput aptamer-based platform to identify circulating biomarkers able to predict occurrence of heart failure (HF), in blood samples collected during hospitalization of patients suffering from a ...
Wilfried Heyse, Vincent Vandewalle, Guillemette Marot, Philippe Amouyel, Christophe Bauters, Florence Pinet   +5 more
doaj   +1 more source

Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes

Antioxidants, 2022
Heart failure, mostly associated with cardiac hypertrophy, is a major cause of illness and death. Oxidative stress causes accumulation of reactive oxygen species (ROS), leading to mitochondrial dysfunction, suggesting that mitochondria-targeted therapies
Victoriane Peugnet, Maggy Chwastyniak, Paul Mulder, Steve Lancel, Laurent Bultot, Natacha Fourny, Edith Renguet, Heiko Bugger, Olivia Beseme, Anne Loyens, Wilfried Heyse, Vincent Richard, Philippe Amouyel, Luc Bertrand, Florence Pinet, Emilie Dubois-Deruy   +15 more
doaj   +1 more source

Une approche centrée sur la personne pour l’analyse des facteurs de stress liés à la pandémie de COVID-19

Promotion de la santé et prévention des maladies chroniques au Canada, 2022
IntroductionLa pandémie de COVID­19 et les effets du confinement qui en ont découlé ont eu un effet néfaste sur la situation sociale, professionnelle et financière des individus.
Ann-Renee Blais, Ève-Marie Blouin Hudon, Matthew Lymburner   +2 more
doaj   +1 more source

Écarts régionaux dans le fardeau économique attribuable au surplus de poids, à la sédentarité et à l’usage du tabac en Colombie-Britannique

Promotion de la santé et prévention des maladies chroniques au Canada, 2016
Introduction : Les taux de prévalence du surplus de poids, de l'usage du tabac et de la sédentarité varient sensiblement d'une région à l'autre en Colombie-Britannique (C.-B.).
H. Krueger, J. M. Koot, D. P. Rasali, S. E. Gustin, E. Cassol, M. Pennock   +5 more
doaj   +1 more source