Results 11 to 20 of about 61,152,383 (170)

Sensibilité des enseignant-es aux facteurs scolaires de risque de décrochage

Schweizerische Zeitschrift für Bildungswissenschaften, 2017
Le décrochage scolaire, phénomène complexe et processuel, est le résultat de facteurs tant internes qu’externes au système scolaire. La présente étude vise à analyser la conscience qu’ont les enseignant-es de l’importance des variables scolaires dans le ...
Anne-Françoise de Chambrier, Valérie Angelucci, Léonie Liechti, Oliver Prosperi   +3 more
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Facteurs environnementaux associés au trouble du spectre de l’autisme : étude de délimitation portant sur les années 2003 à 2013 [PDF]

Promotion de la santé et prévention des maladies chroniques au Canada, 2017
Introduction : Le nombre d’enfants chez lesquels on diagnostique un trouble du spectre de l’autisme (TSA) grimpe rapidement depuis une décennie. L’étiologie de ce trouble est toutefois en grande partie inconnue, même si la contribution de l’environnement
Michelle Ng, Joanne G. de Montigny, Marianna Ofner, Minh T. Do   +3 more
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Cardiac Acetylation in Metabolic Diseases

Biomedicines, 2022
Lysine acetylation is a highly conserved mechanism that affects several biological processes such as cell growth, metabolism, enzymatic activity, subcellular localization of proteins, gene transcription or chromatin structure.
Emilie Dubois-Deruy, Yara El Masri, Annie Turkieh, Philippe Amouyel, Florence Pinet, Jean-Sébastien Annicotte   +5 more
doaj   +1 more source

Desmin aggrephagy in rat and human ischemic heart failure through PKCζ and GSK3β as upstream signaling pathways

Cell Death Discovery, 2021
Post-translational modifications of cardiac proteins could participate to left contractile dysfunction resulting in heart failure. Using a rat model of ischemic heart failure, we showed an accumulation of phosphorylated desmin leading to toxic aggregates
Marion Bouvet, Emilie Dubois-Deruy, Annie Turkieh, Paul Mulder, Victoriane Peugnet, Maggy Chwastyniak, Olivia Beseme, Arthur Dechaumes, Philippe Amouyel, Vincent Richard, Nicolas Lamblin, Florence Pinet   +11 more
doaj   +1 more source

Sepsis-like Energy Deficit Is Not Sufficient to Induce Early Muscle Fiber Atrophy and Mitochondrial Dysfunction in a Murine Sepsis Model

Biology, 2023
Sepsis-induced myopathy is characterized by muscle fiber atrophy, mitochondrial dysfunction, and worsened outcomes. Whether whole-body energy deficit participates in the early alteration of skeletal muscle metabolism has never been investigated.
Alexandre Pierre, Claire Bourel, Raphael Favory, Benoit Brassart, Frederic Wallet, Frederic N. Daussin, Sylvain Normandin, Michael Howsam, Raphael Romien, Jeremy Lemaire, Gaelle Grolaux, Arthur Durand, Marie Frimat, Bruno Bastide, Philippe Amouyel, Eric Boulanger, Sebastien Preau, Steve Lancel   +17 more
doaj   +1 more source

Mitophagy Regulation Following Myocardial Infarction

Cells, 2022
Mitophagy, which mediates the selective elimination of dysfunctional mitochondria, is essential for cardiac homeostasis. Mitophagy is regulated mainly by PTEN-induced putative kinase protein-1 (PINK1)/parkin pathway but also by FUN14 domain-containing 1 (
Annie Turkieh, Yara El Masri, Florence Pinet, Emilie Dubois-Deruy   +3 more
doaj   +1 more source

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

Acta Neuropathologica Communications, 2022
The Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer’s disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms.
Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis, Nicolas Barois, Fabien Delahaye, Bart Dermaut, Jean-Charles Lambert, Marcos R. Costa, Pierre Dourlen   +21 more
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Identification of several eating habits that mediate the association between eating behaviors and the risk of obesity

Obesity Science & Practice, 2022
Objective Eating behaviors play important roles in the development of obesity. A better knowledge of the psychological aspects of eating behaviors in individuals with and without obesity and their consequences on daily eating and lifestyle habits would ...
Estelle Aymes, Gabrielle Lisembard, Jean Dallongeville, Julien Rousseaux, Marie‐Pierre Dumont, Philippe Amouyel, Monique Romon, Aline Meirhaeghe   +7 more
doaj   +1 more source

Identification of patient subtypes based on protein expression for prediction of heart failure after myocardial infarction

iScience, 2023
Summary: This study investigates the ability of high-throughput aptamer-based platform to identify circulating biomarkers able to predict occurrence of heart failure (HF), in blood samples collected during hospitalization of patients suffering from a ...
Wilfried Heyse, Vincent Vandewalle, Guillemette Marot, Philippe Amouyel, Christophe Bauters, Florence Pinet   +5 more
doaj   +1 more source

Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes

Antioxidants, 2022
Heart failure, mostly associated with cardiac hypertrophy, is a major cause of illness and death. Oxidative stress causes accumulation of reactive oxygen species (ROS), leading to mitochondrial dysfunction, suggesting that mitochondria-targeted therapies
Victoriane Peugnet, Maggy Chwastyniak, Paul Mulder, Steve Lancel, Laurent Bultot, Natacha Fourny, Edith Renguet, Heiko Bugger, Olivia Beseme, Anne Loyens, Wilfried Heyse, Vincent Richard, Philippe Amouyel, Luc Bertrand, Florence Pinet, Emilie Dubois-Deruy   +15 more
doaj   +1 more source