Results 131 to 140 of about 3,317,431 (294)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
DECOMPOSITION ANALYSIS OF FACTOR COST SHARES: THE CASE OF GREEK AGRICULTURE
An alternative version of decomposition analysis, based on factor cost shares rather than input demand functions, is presented and applied to Greek agriculture. Decomposition analysis shows that most of the changes in factor cost shares during the period
Katranidis, Stelios D. +2 more
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Nursing Practice TodayMeta-analysis is a vital statistical tool in psychometric research, enabling the synthesis of multiple studies to enhance the reliability and validity of measurement instruments. This study applies meta-analytic techniques to exploratory factor analysis
Hamid Sharif-Nia, Jason W. Osborne
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Simulation Experiments in Practice: Statistical Design and Regression Analysis
In practice, simulation analysts often change only one factor at a time, and use graphical analysis of the resulting Input/Output (I/O) data. The goal of this article is to change these traditional, naïve methods of design and analysis, because ...
Kleijnen, J.P.C.
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Principal Components and Factor Analysis. A Comparative Study.
A comparison between Principal Component Analysis (PCA) and Factor Analysis (FA) is performed both theoretically and empirically for a random matrix X:(n x p) , where n is the number of observations and both coordinates may be very large.
Travaglini, Guido
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Factor models can cope with many variables without running into scarce degrees of freedom problems often faced in a regression-based analysis. In this article we review recent work on dynamic factor models that have become popular in macroeconomic policy
Breitung, Jörg, Eickmeier, Sandra
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
URBAN PLANNING WITH THE AID OF FACTOR ANALYSIS APPROACH: THE CASE OF ISFAHAN MUNICIPALITY [PDF]
Nowadays municipalities play an important role in offering urban services to the citizens. To investigate performance of regional municipalities, different data on living situation must be considered. Thus, we face a multivariate analysis.
Iman NOSOOHI, Ali ZEINAL - HAMADANI
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