Results 101 to 110 of about 12,866,402 (338)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Frontiers in Psychology, 2018 Schema Therapy (ST) is a well-known approach for the treatment of personality disorders. This therapy integrates different theories and techniques into an original and systematic treatment model.
Aristide Saggino +13 more
doaj +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Encephalopathy-causes of formation and their significance from the standpoint of factor analysis
КардиоСоматика, 2013 139 patients with confirmed diagnosis of "dyscirculatory encephalopathy" (DEP) - including 120 men and 19 women, mean age - 47,1 ± 7,6 years were examined.
I. M Starovoytova +2 more
doaj
Derivation of Theory by Means of Factor Analysis or Tom Swift and His Electric Factor Analysis Machine [PDF]
Problems in the use of factor analysis for deriving theory are illustrated by means of an example in which the underlying factors are known. The actual underlying model is simple and it provides a perfect explanation of the data.
J.S. Armstrong
core
OBJECTIVE DESCRIPTION AND CLASSIFICATION OF ENGINEERING JOBS, II: FACTOR ANALYSIS OF THE KEY GROUP DATA FORM [PDF]
, 1956 David Saunders
openalex +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Unified single-cell analysis of testis gene regulation and pathology in five mouse strains
eLife, 2019 To fully exploit the potential of single-cell functional genomics in the study of development and disease, robust methods are needed to simplify the analysis of data across samples, time-points and individuals.
Min Jung +6 more
doaj +1 more source
AN ANALYSIS OF THE PROBLEM OF THE MINIMAL LETHAL DOSE AND ITS RELATIONSHIP TO THE TIME FACTOR. [PDF]
, 1914 Georges Dreyer, E. W. Ainley Walker
openalex +1 more source
Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases
FEBS Letters, EarlyView.
Igor Zivkovic +2 more
wiley +1 more source