Results 131 to 140 of about 5,206,551 (296)
The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription
, 2009 Epithelial tight junctions recruit different types of signalling proteins that regulate cell proliferation and differentiation. Little is known about how such proteins interact functionally and biochemically with each other.
Leefa Chong San, I.V. +9 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
REST, not REST4, is a risk factor associated with radiotherapy plus chemotherapy efficacy in glioma
, 2018 Cuilin Li,1,2 Hecun Zou,1–3 Zhifei Wang,4 Xinyue Tang,1,2 Xitang Fan,4 Ke Zhang,1,2 Jianqiu Liu,1,2 Zhi Li1,2 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China; 2Institute of Clinical Pharmacology ...
Zou H +7 more
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
BMC PediatricsBackground Dental fluorosis is a significant public health issue in many parts of the world, including Sudan, where its prevalence and associated factors among adolescents are not well-documented.
Muhamood Moothedath +3 more
doaj +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2020 Melkamu Tilahun,1 Teshome Gobena,2 Diriba Dereje,2 Mengistu Welde,2 Getachew Yideg3 1Department of Biomedical Sciences (Medical Physiology), College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of ...
Tilahun M +4 more
doaj
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 2013 Background Autism spectrum disorders (ASDs), characterized by impaired social interactions and deficits in verbal and nonverbal communication, are thought to affect 1 in 88 children in the United States.
Anthony J. Russo
core +1 more source
Psychology Research and Behavior Management, 2020 Abinet Teshome,1 Mustefa Glagn,2 Mulugeta Shegaze,2 Beemnet Tekabe,2 Asmare Getie,3 Genet Assefa,3 Dinkalem Getahun,3 Tesfaye Kanko,1 Tamiru Getachew,4 Nuhamin Yenesew,5 Zebene Temtmie,5 Kabtamu Tolosie6 1Department of Biomedical Science, School of ...
Teshome A +11 more
doaj
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source