Results 151 to 160 of about 16,335,704 (243)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Avidity of autoantibodies against type I interferons as a factor associated with neurological complications in severe COVID-19. [PDF]

Front Immunol
Framil M, García-Serrano L, García-García A, Caballero-Segarra I, Gomez-Vazquez JL, Antolí A, Solanich X.   +6 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Preoperative FIB-4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma. [PDF]

Ann Gastroenterol Surg
Nakamura M, Okamura Y, Aramaki O, Yoshida N, Mitsuka Y, Abe H, Yamagishi S, Okumura Y, Pak K, Masuda S.   +9 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Acquired brachial cutaneous dyschromatosis

JAAD Case Reports, 2023
Emily Everdell, BA, Thomas Denize, MD, Hensin Tsao, MD, PhD   +2 more
doaj   +1 more source

Platelet-to-Lymphocyte Ratio as an Independent Factor Associated With Atrial Tachyarrhythmia. [PDF]

Cureus, 2023
Chen C, Tang X, Fan P.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Tooth loss as a factor associated with deterioration of quality and increase in sleep duration: analysis of the 2016-2017 Chilean National Health Survey. [PDF]

BMC Oral Health
Portalier Dublé N, Celis Sersen A, Celis-Dooner J, Sepúlveda Viveros D, Custodio Villanueva C, Vargas Buratovic JP, González Agurto MI, Monsalves Morales N, Soto Marchant M, Ortuño Borroto D.   +9 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source