Results 111 to 120 of about 36,394,742 (371)

Contribution of functional and quantitative genetic variants of Complement Factor H and Factor H-Related (FHR) proteins on renal pathology

open access: yesNefrología (English Edition), 2022
The complement system is a first line of defence against infectious, tumoral or autoimmune processes, and it is constitutively regulated to avoid excessive or unspecific activation. Factor H (FH), a most relevant complement regulator, controls complement
Irene Gómez Delgado   +1 more
doaj  

Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency.

open access: yesJournal of the American Society of Nephrology, 2013
Complement factor H (CFH) is a negative regulator of the alternative pathway of complement, and properdin is the sole positive regulator. CFH-deficient mice (CFH(-/-)) develop uncontrolled C3 activation and spontaneous renal disease characterized by ...
M. Ruseva   +9 more
semanticscholar   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Zgamma Production in pbarp Collisions at sqrt(s)=1.8 TeV and Limits on Anomalous ZZgamma and Zgammagamma Couplings

open access: yes, 1988
We present a study of Z +gamma + X production in p-bar p collisions at sqrt{S}=1.8 TeV from 97 (87) pb^{-1} of data collected in the eegamma (mumugamma) decay channel with the D0 detector at Fermilab.
Abbott, B   +372 more
core   +1 more source

Scientific journals in the SciELO database, indicators of impact and the relative position of Ambiente & Água

open access: yesRevista Ambiente & Água, 2010
This editorial describes the process of periodic evaluation by CAPES, based on commercial indices proposed by companies such as the ISI FI by Thomson Reuters and SCImago by Scopus and public indices as proposed by SciELO and other freely calculated ...
Nelson Wellausen Dias   +1 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Zinc-induced Self-association of Complement C3b and Factor H

open access: yesJournal of Biological Chemistry, 2013
Background: Sub-retinal pigment epithelial deposits contain complement proteins and bioavailable zinc. Results: Ultracentrifugation and x-ray scattering show that >100 μm zinc induces oligomer formation in each of C3, C3u, and C3b, in analogy to Factor H.
R. Nan   +6 more
semanticscholar   +1 more source

Factor H - US? [PDF]

open access: yesNephrology Dialysis Transplantation, 1998
Paul Warwicker   +2 more
openaire   +3 more sources

Constant approximation algorithms for embedding graph metrics into trees and outerplanar graphs

open access: yes, 2010
In this paper, we present a simple factor 6 algorithm for approximating the optimal multiplicative distortion of embedding a graph metric into a tree metric (thus improving and simplifying the factor 100 and 27 algorithms of B\v{a}doiu, Indyk, and ...
Chepoi, Victor   +4 more
core   +3 more sources

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