Effective long-term treatment with moss-produced factor H by overcoming the antibody response in a mouse model of C3G. [PDF]
Tschongov T+8 more
europepmc +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter [PDF]
Bart Vanhaesebroeck+5 more
openalex +1 more source
The Factorization of $H^p$ and the Commutators
openaire +3 more sources
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
Temperature Dependence of the Liquid-Vapor Isotopic Fractionation Factors in CD3H-CH4 and CD3F-CH3F Mixtures [PDF]
Anthony Popowicz+2 more
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
wiley +1 more source
Common Haplotypes within the Chromosome 1q31.3 Region Determine Systemic Concentrations of the Entire Complement Factor H Protein Family. [PDF]
Veuskens BRJ+13 more
europepmc +1 more source
Genetic polymorphism of human factor H (HF,β1H globulin) in Chinese han population in northeast China [PDF]
Shigeyuki Tsunenari+5 more
openalex +1 more source