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Factor H and the pathogenesis of renal diseases
Pediatric Nephrology, 2000Complement factor H is a potent inhibitor of alternative pathway complement activation. The factor H gene, a member of the regulators of complement activation (RCA) gene cluster, encodes two plasma proteins, one 150 kilodaltons (kDa) and one 43 kDa.
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Factor H in the Nutrition of Trout [PDF]
Science, 1928 Clive M. McCay +2 more
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Complement Factor H: Physiology and Pathophysiology
Seminars in Thrombosis and Hemostasis, 2001The human plasma protein factor H, which is a multifunctional, multidomain protein, acts as a central regulator of the complement system. In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3 ...
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Anti-complement-factor H-associated glomerulopathies
Nature Reviews Nephrology, 2016M. Durey +3 more
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The lectin self of complement factor H
Current Opinion in Structural Biology, 2017Complement, a part of the humoral innate immune system, is divided into three pathways. The classical and mannose-binding lectin pathways are triggered by specific recognition of foreign targets. Conversely, the alternative pathway (AP) is actively down-regulated on host tissue.
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A radiation hybrid map of complement factor H and factor H-related genes
Immunogenetics, 1999Díaz-Guillén Ma +2 more
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Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigen
Expert Review of Vaccines, 2015Kate L. Seib +4 more
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