Results 141 to 150 of about 14,184,553 (374)

Prolonged activity of factor IX as a monomeric Fc fusion protein.

Blood, 2010
Treatment of hemophilia B requires frequent infusions of factor IX (FIX) to prophylax against bleeding episodes. Hemophilia B management would benefit from a FIX protein with an extended half-life.
R. Peters, S. Low, George D. Kamphaus, J. Dumont, J. Amari, Qi Lu, Gregory Zarbis-Papastoitsis, Tom J Reidy, E. Merricks, T. Nichols, A. Bitonti   +10 more
semanticscholar   +1 more source

Scanning by DOVAM-S Detects All Unique Sequence Changes in Blinded Analyses: Evidence that the Scanning Conditions Are Generic

BioTechniques, 2000
The [detection of virtually all mutations]-SSCP (DOVAM-S) is a highly sensitive variant of single strand conformation polymorphism (SSCP). Mutations in the factor IX gene were used to find a set of five SSCP conditions that detects virtually all ...
C.H. Buzin, C.Y. Wen, V.Q. Nguyen, G. Nozari, A. Mengos, X. Li, J.S. Chen, Q. Liu, R.A. Gatti, F.K. Fujimura, S.S. Sommer   +10 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Investigating meV-scale Equilibrium Atomic Dynamics with X-Rays: focus on disordered materials [PDF]

Hamon Volume 34 Number 1 2024 p3
This paper reviews non-resonant meV-resolved inelastic x-ray scattering (IXS) as a complementary method to inelastic neutron scattering (INS). Two aspects of IXS that are notable in this context are (1) that IXS allows straightforward measurements of phonons in small (sub-mm, and even $\sim 0.01$ mm) samples with $\sim 1$ meV resolution and excellent Q
arxiv  

Introduction to Quantum Computers and Quantum Algorithms [PDF]

arXiv, 2003
This is a short introduction to Quantum Computing intended for physicists. The basic idea of a quantum computer is introduced. Then we concentrate on Shor's integer factoring algorithm.
arxiv  

Expression of active human factor IX in mammary tissue and of milk non human transgenic mammals [PDF]

, 2002
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention.
Drohan, William N, Velander, William H.
core   +1 more source

The Physiology of Sugar-Cane. IX.·Factors Affecting Photosynthesis and Sugar Storage [PDF]

, 1967
J.C. Waldron, KT Glasziou, T. A. Bull
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Case Report: Severe hemophilia B patient with inhibitor and anaphylaxis reaction to FIX, successfully managed with concizumab prophylaxis therapy

Frontiers in Pediatrics
BackgroundHemophilia B is a rare X-linked disorder characterized by factor IX (FIX) deficiency, leading to spontaneous bleeding episodes predominantly affecting joints and muscles.
Elisa Bonetti, Maria Pia Esposto, Ada Zaccaron, Chiara Guardo, Giulia Caddeo, Matteo Chinello, Rita Balter, Vincenza Pezzella, Virginia Vitale, Simone Cesaro   +9 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source