Results 181 to 190 of about 110,909 (237)

A novel snake venom C-type lectin-like protein modulates blood coagulation by targeting von Willebrand factor and coagulation factor IX. [PDF]

Sci Rep
Zeng FY, Ji RS, Yu XQ, Li YN, Zhang QY, Sun QY.   +5 more
europepmc   +1 more source

Self‐Assembling Peptide Hydrogels Support Stromal Vascular Fraction Viability to Promote In Vivo Nerve Regeneration

Advanced Healthcare Materials, EarlyView.
Stromal vascular fraction (SVF) may enhance nerve repair, especially when delivered in a self‐assembling peptide hydrogel (SAPH). In vitro, softer SAPH increased neuronal explant outgrowth and supported greater SVF viability and proliferation. In a rat sciatic defect, SVF in an optimized SAPH produced motor and sensory recovery equivalent to autograft ...
Liam A. McMorrow, Steffan Llewellyn, Jared McSweeney, Alessandro Faroni, Aline F. Miller, Alberto Saiani, Adam J. Reid   +6 more
wiley   +1 more source

Enhanced procoagulant activity of select hemophilia B causing factor IX variants with emicizumab.

Blood
Lee K, Chau JQ, Suber YB, Sternberg AR, Pishko AM, George LA, Bhoj VG, Doshi BS, Samelson-Jones BJ.   +8 more
europepmc   +1 more source

Assessing health care resource use, outcomes, and costs among Medicaid beneficiaries receiving factor IX prophylaxis for hemophilia B. [PDF]

J Manag Care Spec Pharm
Pauly N, Burrell A, Drelich D, Zhang X, Thiruvillakkat K, Nysenbaum J, Fiori A, Yan S.   +7 more
europepmc   +1 more source

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

The impact of capping health system cost savings on the projected cost-effectiveness of etranacogene dezaparvovec compared with factor IX prophylaxis for the treatment of hemophilia B. [PDF]

J Manag Care Spec Pharm
Sarker J, Tice JA, Rind DM, Pearson SD, Walton SM.   +4 more
europepmc   +1 more source

In Vivo Skin 3‐D Surface Reconstruction and Wrinkle Depth Estimation Using Handheld High Resolution Tactile Sensing

Advanced Healthcare Materials, EarlyView.
A compact handheld GelSight probe reconstructs in vivo 3‐D skin topography with micron‐level precision using a custom elastic gel and a learning‐based surface normal to height map pipeline. The device quantifies wrinkle depth across various body locations and detects changes in wrinkle depth following moisturizer application.
Akhil Padmanabha, Arpit Agarwal, Catherine Li, Austin Williams, Dinesh K. Patel, Sankalp Chopkar, Achu Wilson, Ahmet Ozkan, Wenzhen Yuan, Sonal Choudhary, Arash Mostaghimi, Zackory Erickson, Carmel Majidi   +12 more
wiley   +1 more source

Correlation of antigen expression with epigenetic modifications after rAAV delivery of a human factor IX variant in mice and rhesus macaques. [PDF]

Mol Ther
Pekrun K, Stephens CJ, Gonzalez-Sandoval A, Goswami A, Zhang F, Tarantal AF, Blouse G, Kay MA.   +7 more
europepmc   +1 more source

Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies

Advanced Healthcare Materials, EarlyView.
Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer, Dolores J. Salander, Witold Szymanski, Johannes Graumann, Yukai Wang, Kai Zhao, Jörg W. Bartsch, María Gómez‐Serrano, Daniel Bachurski, Silke Reinartz, Elke von Pogge von Strandmann   +10 more
wiley   +1 more source

Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction. [PDF]

J Thromb Haemost
Coyle CW, Knight KA, Brown HC, George SN, Denning G, Branella GM, Childers KC, Spiegel PC, Spencer HT, Doering CB.   +9 more
europepmc   +1 more source