Results 21 to 30 of about 1,787,206 (260)

Billiard representation for multidimensional multi-scalar cosmological model with exponential potentials

open access: yes, 2003
Multidimensional cosmological-type model with n Einstein factor spaces in the theory with l scalar fields and multiple exponential potential is considered.
Dehnen, H.   +2 more
core   +1 more source

Electromagnetic Structure of the Trinucleons [PDF]

open access: yes, 1998
The electromagnetic form factors of the trinucleons 3H and 3He are calculated with wave functions obtained with the Argonne AV18 two-nucleon and Urbana IX three-nucleon interactions.
Marcucci, L. E.   +2 more
core   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Factor IX binding to collagen [PDF]

open access: yesJournal of Thrombosis and Haemostasis, 2009
At a site of vascular injury, numerous cellular and protein constituents of blood bind to components of extracellular matrices in the vessel wall. These interactions are critical for normal clot formation. In this issue of the Journal of Thrombosis and Haemostasis, Gui et al.
openaire   +3 more sources

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren   +16 more
wiley   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Deuteron distribution in nuclei and the Levinger's factor [PDF]

open access: yes, 2003
We compute the distribution of quasideuterons in doubly closed shell nuclei. The ground states of $^{16}$O and $^{40}$Ca are described in $ls$ coupling using a realistic hamiltonian including the Argonne $v_{8}^\prime$ and the Urbana IX models of two ...
A. Akmal   +39 more
core   +2 more sources

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow [PDF]

open access: yes, 2015
The importance of factor Xa generation in thrombus formation has not been studied extensively so far. Here, we used mice deficient in either factor VIII or factor IX to determine the role of platelet-stimulated tenase activity in the formation of ...
Heemskerk, Johan W. M.   +4 more
core   +3 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

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