Results 21 to 30 of about 14,161,714 (418)
Factor IX and thrombosis [PDF]
British Journal of Haematology, 2001 No abstract available.
openaire +3 more sources
Importance of factor-IX-dependent prothrombinase formation - the Josso Pathway,- in clotting plasma [PDF]
, 1989 We report a study on the importance of factor IX activation in thromboplastin-dependent coagulation in plasma. Diluted, CaCl2-containing thromboplastin solutions at constant phospholipid concentration were used to trigger the coagulation in plasma from ...
Beguin, S., Hemker, H.C., Xi, Ma
core +2 more sources
The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer [PDF]
, 2002 Regulation by hypoxia may underlie the expression of vascular endothelial growth factor in bladder cancer. We have compared the distribution of vascular endothelial growth factor mRNA with a hypoxia marker, carbonic anhydrase 9 (CA IX).
Cranston, D +8 more
core +2 more sources
Long-term safety and efficacy of factor IX gene therapy in hemophilia B.
New England Journal of Medicine, 2014 BACKGROUND In patients with severe hemophilia B, gene therapy that is mediated by a novel self-complementary adeno-associated virus serotype 8 (AAV8) vector has been shown to raise factor IX levels for periods of up to 16 months.
A. Nathwani +29 more
semanticscholar +1 more source
Turkish Journal of Hematology, 2014 OBJECTIVE: Hemophilia B is caused by coagulation defects in the factor IX gene located in Xq27.1 on the X chromosome. A wide range of mutations, showing extensive molecular heterogeneity, have been described in hemophilia B patients.
Dong Hua Cao +7 more
doaj +1 more source
Case Reports in Transplantation, 2020 Herein, we discuss a case of a 39-year-old male with hemophilia B, who developed end-stage liver disease secondary to nonalcoholic steatohepatitis, that underwent orthotopic liver transplantation (OLT) as a curative means for his liver disease and ...
Jesse E. Harris +3 more
doaj +1 more source
Construction of Human Factor IX Expression Vectors in Retroviral Vector Frames Optimized for Muscle Cells [PDF]
, 1996 Overview summary Skeletal muscle cells may serve as an efficient medium for systemic production of transgene products in a gene therapy. Retroviral vector constructs were prepared using human factor IX minigenes, various muscle-specific or nonspecific ...
Kurachi, Kotoku +6 more
core +1 more source
Hemophilia B Gene Therapy with a High‐Specific‐Activity Factor IX Variant
New England Journal of Medicine, 2017 Background The prevention of bleeding with adequately sustained levels of clotting factor, after a single therapeutic intervention and without the need for further medical intervention, represents an important goal in the treatment of hemophilia. Methods
Lindsey A. George +27 more
semanticscholar +1 more source
The B-team: Equal but different?
The Journal of Haemophilia Practice, 2021 As a person with haemophilia B, I have known there are differences between haemophilia A and haemophilia B and their respective treatment throughout my life – though I was shocked when I learnt about the impact inhibitors can have when it comes to ...
Pembroke Luke
doaj +1 more source
Bianchi IX cosmologies in the Einstein-Skyrme system in a sector with non-trivial topological charge [PDF]
Phys. Rev. D 99, 044035 (2019), 2019 The dynamics of the most general Bianchi IX cosmology with three time dependent scale factors for the Einstein-Skyrme system is analyzed. For the Skyrmion, a generalized hedgehog ansatz with unit baryon charge is introduced. The most remarkable feature of this ansatz is that, in the above topologically non-trivial sector with unit topological charge ...
arxiv +1 more source