Results 311 to 320 of about 14,184,553 (374)
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Factor IX Deficiency in Nephrosis
Annals of Internal Medicine, 1971Excerpt To the editor: The report by Natelson and co-workers in the September issue (Ann Intern Med73:373-378, 1970) describes an additional well-documented example of acquired factor IX deficiency...
G R, Honig, E A, Natelson
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The Activation of Human Factor IX
Thrombosis and Haemostasis, 1975SummaryThe activation of factor IX purified from human plasma has been studied. Factor XIa and kallikrein separately activated factor IX to factor IXa. In both cases factor IX a had an apparent molecular weight of about 42–45000 in sodium dodecyl sul-phate-polyacrylamide disc gel electrophoresis compared with a molecular weight of about 70000 for the ...
Prydz H, Bjarne Østerud, Laake K
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Activation of Factor IX by Factor XIa
Trends in Cardiovascular Medicine, 2000Blood coagulation factor IX is activated during hemostasis by two distinct mechanisms. Activation through factor VIIa/tissue factor occurs early in the course of fibrin clot formation. Activation by factor XIa appears to be important for maintaining the integrity of the clot over time.
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Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts.
Science, 1997Ovine primary fetal fibroblasts were cotransfected with a neomycin resistance marker gene (neo) and a human coagulation factor IX genomic construct designed for expression of the encoded protein in sheep milk. Two cloned transfectants and a population of
A. Schnieke +8 more
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Pharmacokinetics of factor VIII and factor IX
Haemophilia, 2003Summary. A survey of principal pharmacokinetic (PK) studies on factor VIII (FVIII) and factor IX (FIX) plasma‐ and rDNA‐derived concentrates, analysed by means of the PKRD program, has been performed. Notwithstanding the accurate definition of the study design, released in 1991 by the Scientific and Standardization Committee of the International ...
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Factor IX activity and factor IX antigen in haemophilia B carriers
Thrombosis Research, 1975Abstract Examinations performed on the female relatives of haemophilia B patients suggest that factor IX activity is significantly reduced in the carriers of haemophilia B. In the carriers of haemophilia B− the amount of factor IX antigen is in correlation with factor IX activity, while in the carriers of the B+ variant the amount of factor IX ...
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Purification of human factor IX
Thrombosis Research, 1977Abstract Factor IX was isolated from human plasma by a six-step procedure employing adsorption to DE-52 cellulose in batches, aluminium hydroxide adsorption, affinity chromatography on heparin-coupled Sepharose, preparative polyacrylamide disc gel electrophoresis, immunosorbent absorption, and DE-52 cellulose chromatography.
K. Laake +4 more
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An RNA Aptamer That Discriminates Bovine Factor IX from Human Factor IX
The Journal of Biochemistry, 2006An RNA aptamer has been selected by SELEX against bovine factor IX using an RNA pool containing 74-nucleotides randomized region. Selected RNA aptamer (Clone 5) could discriminate bovine factor IX effectively from human factor IX. Interestingly, the nucleotide regions 73-78 and 80-83 of the selected aptamer were determined to be important for bovine ...
Subash C. B. Gopinath +3 more
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Coagulation factor IX: Successful surgical experience with a purified factor IX concentrate
American Journal of Hematology, 1992AbstractThe use of plasma‐derived coagulation factor concentrates has been marked by the transmission of viral agents. Infusions of factor IX complex concentrates have been additionally complicated by inappropriate thrombosis. Use of these concentrates in the neonate, in those with liver disease, and in surgical patients results in increased risk for ...
Jonathan C. Goldsmith +7 more
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Factor IX complex for the correction of traumatic coagulopathy
Journal of Trauma and Acute Care Surgery, 2012BACKGROUND: Damage control resuscitation advocates correction of coagulopathy; however, options are limited and expensive. The use of prothrombin complex concentrate (PCC), also known as factor IX complex, can quickly accelerate reversal of coagulopathy ...
B. Joseph +9 more
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