Results 91 to 100 of about 12,711,395 (233)

On the Synthesis and Reactivity of Potassium Phosphinophosphido Dithioformates

European Journal of Inorganic Chemistry, Volume 28, Issue 31, November 1, 2025.
Sterically hindered potassium phosphinophosphido dithioformates K[TerP(CS2)PR2] (R = iPr, tBu) are synthesized from the conversion of the potassium phosphinophosphides K[TerP–PR2] with CS2. In solution, the dithioformate species rearrange to anionic phosphanylthioketones K[TerPC(=S)–P(S)R2].
Karsten Paul Lüdtke, Axel Schulz, Lilian Sophie Szych   +2 more
wiley   +1 more source

Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.

PLoS Computational Biology, 2010
Blood function defines bleeding and clotting risks and dictates approaches for clinical intervention. Independent of adding exogenous tissue factor (TF), human blood treated in vitro with corn trypsin inhibitor (CTI, to block Factor XIIa) will generate ...
Manash S Chatterjee, William S Denney, Huiyan Jing, Scott L Diamond   +3 more
doaj   +1 more source

The Mirage of Factor Equivalence: Examining the Complexities of Non‐Factor Therapies in Haemophilia

Haemophilia, Volume 31, Issue 6, Page 1170-1175, November 2025.
ABSTRACT Background This article provides a critical analysis of the ‘factor equivalence’ concept as applied to non‐factor therapies (NFTs) for haemophilia, highlighting its limitations and clinical implications. Although factor equivalence estimates serve as a comparative tool for evaluating pro‐coagulant effects across different therapies, they may ...
Yesim Dargaud, Arianna Colombo, Maria Elisa Mancuso   +2 more
wiley   +1 more source

Platelet Receptor Occupancy with Factor IXa Promotes Factor X Activation

Journal of Biological Chemistry, 1989
To investigate the activated platelet surface as a locus for factor X activation, the functional consequences of factor IXa binding to platelets were studied. The concentration of factor IXa required for half-maximal rates of factor X activation in the presence of factor VIIIa and thrombin-activated platelets was 0.53 nM, which is close to the Kd (0.56
S S, Ahmad, R, Rawala-Sheikh, P N, Walsh
openaire   +2 more sources

Neurocognitive Impairment in Inherited Metabolic Disorders due to Intoxication and Energy Defects: A Systematic Review

Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT Inherited metabolic disorders (IMD) can disrupt brain development and functioning, leading to cognitive and behavioral abnormalities. This systematic review aims to provide a comprehensive synthesis of the evidence regarding neurocognitive impairments in intoxication IMD due to the accumulation of small molecule disorders and energy‐related ...
Marta Gil‐González, Carolina Arias, Jean‐Marie Saudubray, Roser Colomé‐Roura, Ángeles García‐Cazorla   +4 more
wiley   +1 more source

3D QSAR and Pharmacophore Modelling of Selected Benzimidazole Derivatives as Factor IXa Inhibitors

, 2017
Anticoagulants are used for the prevention and treatment of venous and arterial thromboembolism. Factor IXa plays an important role in coagulation cascade and is a validated target for development of potent selective new antithrombotic agents.
Santosh S. Kumbhar, P. Choudhari, M. Bhatia   +2 more
semanticscholar   +1 more source

Modified clot waveform analysis to measure plasma coagulation potential in the presence of the anti‐factor IXa/factor X bispecific antibody emicizumab: comment

Journal of Thrombosis and Haemostasis, 2018
A patient with hemophilia A had severe coagulation factor VIII (FVIII) deficiency and required injection with FVIII concentrates two or three times a week.
T. Matsumoto, H. Wada, H. Toyoda, M. Hirayama, Y. Yamashita, N. Katayama   +5 more
semanticscholar   +1 more source

Single‐Cell RNA Analysis Reveals Reduced Frequency and Activity of CXCR5+ Atypical Memory B Cells in Islet Xenotransplantation Treated With Clinically Applicable Immunosuppressants Including Belimumab

Xenotransplantation, Volume 32, Issue 5, September/October 2025.
ABSTRACT Background Porcine‐to‐human islet xenotransplantation offers a promising solution to type 1 diabetes. This study investigates the use of Belimumab, a human monoclonal antibody that inhibits B cell activating factor (BAFF) as part of an immunosuppressive regimen in porcine‐to‐non‐human primate xenotransplantation.
Yuji Lee, Ji Hwan Moon, Hyun Je Kim, Daesik Kim, Yong‐Hee Kim, Jong‐Min Kim, Chung‐Gyu Park   +6 more
wiley   +1 more source

Vortices, Q-balls and Domain Walls on Dielectric M2-branes

, 2008
We study BPS solitons in N=6 U(N) \times U(N) Chern-Simons-matter theory deformed by an F-term mass. The F-term mass generically breaks N=6 supersymmetry down to N=2.
C. Krishnan, Claus Montonen, H. Lin, I. Bena, J. Bagger, J. Gomis, J. KIm, J. Polchinski, K. Hanaki, K. Hosomichi, M. Benna, Masato Arai, O. Aharony, R.C. Myers, S. Terashima, Shin Sasaki, T. Fujimori   +16 more
core   +2 more sources

Real‐World Treatment Patterns and Outcomes in Patients With Relapsed/Refractory Multiple Myeloma and 1–3 Prior Lines of Therapy: Optum Database

Cancer Medicine, Volume 14, Issue 15, August 2025.
ABSTRACT Background Early (often continuous) treatment of multiple myeloma (MM) with lenalidomide has become common practice, leading to an increase in lenalidomide‐refractory disease. Methods We report real‐world treatment patterns, health care resource utilization (HCRU), and outcomes for patients with lenalidomide‐refractory MM using data from Optum
Binod Dhakal, Hermann Einsele, Jordan M. Schecter, William Deraedt, Nikoletta Lendvai, Ana Slaughter, Carolina Lonardi, Sandhya Nair, Nirosha Elsem Varghese, Jianming He, Akshay Kharat, Seina Lee, Patricia Cost, Ravi Potluri, Mythili Koneru, Nitin Patel, Erika Florendo, Paula Rodriguez‐Otero, Kwee Yong   +18 more
wiley   +1 more source