Green Synthesis and Catalysis, 2022 A metal-free approach for the synthesis of 3-trifluoromethyl-1,2,4-triazoles via I2-mediated oxidative cyclization of readily accessible trifluoroacetimidohydrazides with N,N-dimethylformamide (DMF) has been disclosed.
Shu-Ning Lu +4 more
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Correlation of factor IXa subsite modulations with effects on substrate discrimination. [PDF]
J Thromb Haemost, 2012 Neuenschwander PF +3 more
europepmc +3 more sources
Heparin-stimulated inhibition of factor IXa generation and factor IXa neutralization in plasma [PDF]
Blood, 1990 Generation and inhibition of activated factor IXa was studied in factor XIa-activated plasma containing 4 mmol/L free calcium ions and 20 mumol/L phospholipid (25 mol% phosphatidylserine/75 mol% phosphatidylcholine). Interference of other (activated) clotting factors with the factor IXa activity measurements could be avoided by using a highly specific ...
Pieters, J., Lindhout, T., Willems, G.
openaire +3 more sources
Role of crotoxin in coagulation: novel insights into anticoagulant mechanisms and impairment of inflammation-induced coagulation [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: Snake venom phospholipases A2 (svPLA2) are biologically active toxins, capable of triggering and modulating a wide range of biological functions.
Bruna Terada Gimenez +7 more
doaj +1 more source
Factor IXa Inhibitors as Novel Anticoagulants [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 Currently available anticoagulants are limited by modest therapeutic benefits, narrow clinical applications, increased bleeding risk, and drug-induced thrombophilia. Because factor IX plays a pivotal role in tissue factor (TF)–mediated thrombin generation, it may represent a promising target for drug development.
Emily L, Howard +3 more
openaire +2 more sources
Porcine Corneal Tissue and Xenozoonotic Risks: A Review of the Current Evidence. [PDF]
XenotransplantationABSTRACT Corneal opacities affect millions worldwide, with corneal transplantation as the primary treatment. However, donor shortages remain a challenge, leaving thousands waiting for transplants. Xenotransplantation using porcine corneas has emerged as a promising alternative due to anatomical and physiological similarities with human corneas ...
Moreira R +13 more
europepmc +2 more sources
Simukunin from the salivary glands of the black fly Simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses. [PDF]
PLoS ONE, 2012 BACKGROUND: Black flies (Diptera: Simuliidae) feed on blood, and are important vectors of Onchocerca volvulus, the etiolytic agent of River Blindness.
Hitoshi Tsujimoto +5 more
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Recombinant factor VIIa addition to haemophilic blood perfused over collagen/tissue factor can sufficiently bypass the factor IXa/VIIIa defect to rescue fibrin generation. [PDF]
Haemophilia, 2017 Li R +4 more
europepmc +2 more sources
Molecular Therapy: Nucleic Acids, 2017 The long blood circulatory property of human serum albumin, due to engagement with the cellular recycling neonatal Fc receptor (FcRn), is an attractive drug half-life extension enabling technology. This work describes a novel site-specific albumin double-
Matthias Kuhlmann +12 more
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Fruit Research, 2023 Ethylene plays an important role in grape ripening, acting through ethylene response factors (ERFs) that are downstream of ethylene signaling pathways, yet little else is known about these molecular mechanisms.
Zhiqian Li +11 more
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