Results 41 to 50 of about 12,711,395 (233)
Lignosulfonic Acid Sodium Is a Noncompetitive Inhibitor of Human Factor XIa
Pharmaceuticals, 2021 The anticoagulant activity of lignosulfonic acid sodium (LSAS), a non-saccharide heparin mimetic, was investigated in this study. LSAS is a relatively safe industrial byproduct with similar polyanionic characteristics to that of heparin.
Srabani Kar +3 more
doaj +1 more source
Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]
, 2013 Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba +10 more
core +3 more sources
Exploring potential anticoagulant drug formulations using thrombin generation test
Biochemistry and Biophysics Reports, 2016 Many anticoagulant drugs inhibiting proteins of the coagulation cascade have been developed. The main targets of anticoagulant drugs are thrombin and factor Xa; inhibiting these factors delays thrombus growth, thus preventing thrombosis while increasing ...
Elena Zavyalova, Alexey Kopylov
doaj +1 more source
Two-Point Functions of Coulomb Gauge Yang-Mills Theory [PDF]
, 2007 The functional approach to Coulomb gauge Yang-Mills theory is considered within the standard, second order, formalism. The Dyson-Schwinger equations and Slavnov-Taylor identities concerning the two-point functions are derived explicitly and one-loop ...
A. Cucchieri +5 more
core +1 more source
BMC Research Notes, 2012 Background Epitope-mapping of infectious agents is essential for pathogenesis studies. Since polyclonal antibodies (PAbs) and monoclonal antibodies (MAbs) are always polyspecific and can react with multiple epitopes, it is important to distinguish ...
Falconar Andrew K I
doaj +1 more source
Localization of Factor IXa and Factor VIIIa Interactive Sites [PDF]
Journal of Biological Chemistry, 1995 The contribution of the catalytic and noncatalytic domains of factor IXa to the interaction with its cofactor, factor VIIIa, was evaluated. Two proteolytic fragments of factor IXa, lacking some or all of the serine protease domain, failed to mimic the ability of factor IXa to enhance the reconstitution of factor VIIIa from isolated A1/A3-C1-C2 dimer ...
L M, O'Brien, L V, Medved, P J, Fay
openaire +2 more sources
Arteriosclerosis, Thrombosis and Vascular Biology, 2020 Emicizumab is a humanized anti-FIXa/FX (factor IXa/X) bispecific monoclonal antibody that mimics FVIIIa (activated factor VIII) cofactor function. The hemostatic efficacy of emicizumab has been confirmed in clinical studies of patients with hemophilia A,
K. Yada, K. Nogami
semanticscholar +1 more source
Phospholipids as dynamic participants in biological processes
Journal of Lipid Research, 1984 Phospholipids are described as active biological molecules. Three distinctly different roles are examined. The first centers on protein-lipid interactions and the lipid requirement expressed by certain enzymes. This category is illustrated by two soluble
D J Hanahan, D R Nelson
doaj +1 more source
Discovery of Benzyl Tetraphosphonate Derivative as Inhibitor of Human Factor Xia
ChemistryOpen, 2020 The inhibition of factor XIa (FXIa) is a trending paradigm for the development of new generations of anticoagulants without a substantial risk of bleeding.
Srabani Kar +2 more
doaj +1 more source
The Kinematic Algebras from the Scattering Equations [PDF]
, 2013 We study kinematic algebras associated to the recently proposed scattering equations, which arise in the description of the scattering of massless particles.
Monteiro, Ricardo, O'Connell, Donal
core +2 more sources