Results 51 to 60 of about 12,711,395 (233)
Neurobiology of Disease, 2017 Minimal traumatic brain injury (MTBI) often transforms into chronic neuropsychiatric conditions including anxiety, the underlying mechanisms of which are largely unknown. In the present study, we employed the closed-head injury paradigm to induce MTBI in
Sneha Sagarkar +5 more
doaj +1 more source
Haematologica, 2020 The treatment or prevention of bleeding in patients with hemophilia A relies on replacement therapy with different factor VIII (FVIII)-containing products or on the use of by-passing agents, i.e., activated prothrombin complex concentrates or recombinant
Jules Russick +8 more
doaj +1 more source
Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity. [PDF]
PLoS ONE, 2013 In hemophilia A, routine prophylaxis with exogenous factor VIII (FVIII) requires frequent intravenous injections and can lead to the development of anti-FVIII alloantibodies (FVIII inhibitors).
Zenjiro Sampei +18 more
doaj +1 more source
Some novel hybrid quinazoline-based heterocycles as potent cytotoxic agents
Research in Pharmaceutical Sciences, 2022 Background and purpose: In this study, some new cytotoxic hybrid structures were synthesized by combining pyrazolinone and imidazolinone rings with quinazoline pharmacophores. Experimental approach: The benzoxazinone, pyrazolo-quinazoline fused ring, and
Mahla Malekzadeh +5 more
doaj +1 more source
Critical current and stability effects between 0 and 6 tesla in mono and multifilamentary NbTi conductors having a CuNi matrix [PDF]
, 1985 We investigated the current carrying capacities of ten NbTi superconductors having a CuNi matrix with diameters between 50 and 300 ¿m as function of an applied magnetic field of 0 to 6 tesla.
Kate, H.H.J. ten +2 more
core +3 more sources
Platelet Biochemistry and Morphology after Cryopreservation [PDF]
, 2020 Platelet cryopreservation has been investigated for several decades as an alternative to room temperature storage of platelet concentrates. The use of dimethylsulfoxide as a cryoprotectant has improved platelet storage and cryopreserved concentrates can ...
Compernolle, Veerle +2 more
core +1 more source
Haematologica, 2019 Rendering coagulation factor X sensitive to thrombin was proposed as a strategy that can bypass the need for factor VIII. In this paper, this non-replacement strategy was evaluated in vitro and in vivo in its ability to correct factor VIII but also ...
Toufik Abache +10 more
doaj +1 more source
The effect of emicizumab and bypassing agents in patients with hemophilia – An in vitro study
Research and Practice in Thrombosis and Haemostasis, 2021 Background Emicizumab is a nonfactor replacement therapy for hemophilia A (HA) and is a bispecific monoclonal antibody mimicking factor VIII by binding both factors IXa and X.
Nina Haagenrud Schultz +3 more
doaj +1 more source
The Significance of Circulating Factor IXa in Blood [PDF]
Journal of Biological Chemistry, 2004 The presence of activation peptides (AP) of the vitamin K-dependent proteins in the phlebotomy blood of human subjects suggests that active serine proteases may circulate in blood as well. The goal of the current study was to evaluate the influence of trace amounts of key coagulation proteases on tissue factor-independent thrombin generation using ...
Saulius, Butenas +4 more
openaire +2 more sources
Mapping DSP algorithms to a reconfigurable architecture Adaptive Wireless Networking (AWGN) [PDF]
, 2003 This report will discuss the Adaptive Wireless Networking project. The vision of the Adaptive Wireless Networking project will be given. The strategy of the project will be the implementation of multiple communication systems in dynamically ...
Rauwerda, Gerard
core +7 more sources