Results 191 to 200 of about 2,453,026 (292)

Congenital Afibrinogenemia With Coexisting Factor V Leiden Mutation Complicated by Budd-Chiari Syndrome: A Case Report. [PDF]

Cureus
Boutari RA, Hsayan FI, Mallah F, Diab M.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Activation of â Catenin During Hepatocarcinogenesis in Transgenic Mouse Models: Relationships to Phenotype and Tumor Grade [PDF]

, 2001
CALVISI D. F, FACTOR V. M, LOI, ROBERTO, AND THORGEIRSSON S. S.   +3 more
core  

Impact of factor V Leiden on outcomes following coronary artery bypass grafting: a national inpatient sample analysis. [PDF]

Front Cardiovasc Med
Czaplicki A, Rensted A, Blee S, Blaney E, Zurob S, Tauseef A, Abdul Jabbar AB.   +6 more
europepmc   +1 more source

Factor V Leiden and Thrombophilia

New England Journal of Medicine, 1995
P, Hopmeier, W, Krugluger
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Basic regions of factor V and tissue factor pathway inhibitor mediate heavy chain and acidic region interactions on factor V revealed by tethered chemical cleavage. [PDF]

J Thromb Haemost
Ayombil F, Toso R, Camire RM.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A propensity score-matched study including 250,000 patients with Factor V Leiden shows significantly increased mortality in comparison with individuals without thrombophilia. [PDF]

Public Health Pract (Oxf)
Hertel M, Heiland M, Nahles S, Preissner S, Preissner R.   +4 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source