Results 261 to 270 of about 31,202,450 (314)
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The International Journal of Biochemistry & Cell Biology, 2004
The coagulation cascade involves sequential enzymatic activations of serine protease zymogens that converge on the generation of thrombin. Factor V (FV) takes part in this process as a component of the prothrombinase complex. Besides its role as procoagulant factor, it is also involved in the physiologic anticoagulant pathway, by participating in the ...
S. Duga, R. Asselta, M.L. Tenchini
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The coagulation cascade involves sequential enzymatic activations of serine protease zymogens that converge on the generation of thrombin. Factor V (FV) takes part in this process as a component of the prothrombinase complex. Besides its role as procoagulant factor, it is also involved in the physiologic anticoagulant pathway, by participating in the ...
S. Duga, R. Asselta, M.L. Tenchini
openaire +4 more sources
The International Journal of Biochemistry & Cell Biology, 1997
Factor V is a single chain glycoprotein that plays an essential role in the regulation of blood coagulation. After initiation of coagulation, factor V is converted into factor Va through limited proteolysis. Factor Va acts as protein cofactor in the prothrombin-activating complex, which is comprised of the serine protease factor Xa, Ca2+ ions and a ...
J, Rosing, G, Tans
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Factor V is a single chain glycoprotein that plays an essential role in the regulation of blood coagulation. After initiation of coagulation, factor V is converted into factor Va through limited proteolysis. Factor Va acts as protein cofactor in the prothrombin-activating complex, which is comprised of the serine protease factor Xa, Ca2+ ions and a ...
J, Rosing, G, Tans
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A Comprehensive Overview of Coagulation Factor V and Congenital Factor V Deficiency
Seminars in Thrombosis and Hemostasis, 2019Coagulation factor (F) V is a glycoprotein that plays an essential role in the formation of the prothrombinase complex, which is critical for progressing clot formation.
S. Tabibian +8 more
semanticscholar +1 more source
JAMA
This JAMA Insights explores factor V Leiden, an inherited thrombophilia, and its association with venous and arterial thrombosis, how it affects pregnancy outcomes, and testing.
Karlyn A, Martin, Mary, Cushman
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This JAMA Insights explores factor V Leiden, an inherited thrombophilia, and its association with venous and arterial thrombosis, how it affects pregnancy outcomes, and testing.
Karlyn A, Martin, Mary, Cushman
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Hereditary Labile Factor (Factor V) Deficiency
JAMA, 1961Hereditary labile factor (Factor V) deficiency is transmitted as an autosomal recessive. Only individuals who inherit the defective gene from both parents are bleeders. In the family studied, the father is Greek while the mother is Polish. The diagnosis is made by determining the prothrombin time by the one-stage method, which is completely corrected ...
I A, FRIEDMAN +4 more
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Factor V Leiden: a disorder of factor V anticoagulant function
Current Opinion in Hematology, 2004Activated protein C (APC) resistance, which is often associated with the factor V R506Q (FV Leiden) mutation, is a common risk factor for venous thrombosis. Study of the mechanism of APC resistance has revealed that coagulation FV stimulates the APC-catalysed inactivation of FVIIIa, and that this anticoagulant function of FV is impaired in FV Leiden ...
Elisabetta, Castoldi, Jan, Rosing
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Combined Factor V and Factor VIII Deficiency
Seminars in Thrombosis and Hemostasis, 2009Combined deficiency of factor V (FV) and factor VIII (FVIII) (F5F8D, or FV+FVIII) is a autosomal recessive bleeding disorder caused by mutations in genes encoding two components of the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC-53), that is, lectin mannose binding protein ( LMAN1) and multiple coagulation factor deficiency 2 ...
Marta, Spreafico, Flora, Peyvandi
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Factor V and Combined Factor V and VIII Deficiency
2018This chapter outlines the pathophysiology, clinical presentation, inheritance and incidence of factor V deficiency and combined factors V and VIII deficiency. The chapter describes the interaction with pregnancy and discusses the medical and anesthetic management of pregnant women with factor V deficiency or combined factors V and VIII deficiency.
James P. R. Brown, Joanne Douglas
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1993
Publisher Summary The proteolytic activation of prothrombin is catalyzed by an enzyme complex composed of the serine protease factor Xa reversibly associated with the cofactor factor Va on membranes containing negatively charged phospholipid in the presence of calcium ions.
Michael Kalafatis +3 more
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Publisher Summary The proteolytic activation of prothrombin is catalyzed by an enzyme complex composed of the serine protease factor Xa reversibly associated with the cofactor factor Va on membranes containing negatively charged phospholipid in the presence of calcium ions.
Michael Kalafatis +3 more
openaire +1 more source