Results 251 to 260 of about 2,453,026 (292)
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The International Journal of Biochemistry & Cell Biology, 1997
Factor V is a single chain glycoprotein that plays an essential role in the regulation of blood coagulation. After initiation of coagulation, factor V is converted into factor Va through limited proteolysis. Factor Va acts as protein cofactor in the prothrombin-activating complex, which is comprised of the serine protease factor Xa, Ca2+ ions and a ...
J, Rosing, G, Tans
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Factor V is a single chain glycoprotein that plays an essential role in the regulation of blood coagulation. After initiation of coagulation, factor V is converted into factor Va through limited proteolysis. Factor Va acts as protein cofactor in the prothrombin-activating complex, which is comprised of the serine protease factor Xa, Ca2+ ions and a ...
J, Rosing, G, Tans
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The International Journal of Biochemistry & Cell Biology, 2004
The coagulation cascade involves sequential enzymatic activations of serine protease zymogens that converge on the generation of thrombin. Factor V (FV) takes part in this process as a component of the prothrombinase complex. Besides its role as procoagulant factor, it is also involved in the physiologic anticoagulant pathway, by participating in the ...
S. Duga, R. Asselta, M.L. Tenchini
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The coagulation cascade involves sequential enzymatic activations of serine protease zymogens that converge on the generation of thrombin. Factor V (FV) takes part in this process as a component of the prothrombinase complex. Besides its role as procoagulant factor, it is also involved in the physiologic anticoagulant pathway, by participating in the ...
S. Duga, R. Asselta, M.L. Tenchini
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Factor V Leiden: a disorder of factor V anticoagulant function
Current Opinion in Hematology, 2004Activated protein C (APC) resistance, which is often associated with the factor V R506Q (FV Leiden) mutation, is a common risk factor for venous thrombosis. Study of the mechanism of APC resistance has revealed that coagulation FV stimulates the APC-catalysed inactivation of FVIIIa, and that this anticoagulant function of FV is impaired in FV Leiden ...
Elisabetta, Castoldi, Jan, Rosing
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JAMA
This JAMA Insights explores factor V Leiden, an inherited thrombophilia, and its association with venous and arterial thrombosis, how it affects pregnancy outcomes, and testing.
Karlyn A, Martin, Mary, Cushman
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This JAMA Insights explores factor V Leiden, an inherited thrombophilia, and its association with venous and arterial thrombosis, how it affects pregnancy outcomes, and testing.
Karlyn A, Martin, Mary, Cushman
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Factor V and Combined Factor V and VIII Deficiency
2018This chapter outlines the pathophysiology, clinical presentation, inheritance and incidence of factor V deficiency and combined factors V and VIII deficiency. The chapter describes the interaction with pregnancy and discusses the medical and anesthetic management of pregnant women with factor V deficiency or combined factors V and VIII deficiency.
James P. R. Brown, Joanne Douglas
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A Comprehensive Overview of Coagulation Factor V and Congenital Factor V Deficiency
Seminars in Thrombosis and Hemostasis, 2019AbstractCoagulation factor (F) V is a glycoprotein that plays an essential role in the formation of the prothrombinase complex, which is critical for progressing clot formation. FV deficiency is a rare bleeding disorder with an estimated incidence of one per 1 million in the general population.
Shadi, Tabibian +8 more
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Factor V in an Industrial Population
British Journal of Haematology, 1976Summary. Factor‐V levels have been measured in a random sample of 626 men and 307 women working in a variety of occupations in North West London. The method is an automated one‐stage assay using the same batch of freeze‐dried thromboplastin, all results being expressed in terms of the same freeze‐dried standard plasma; it has been shown that only one ...
M, Brozović +5 more
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Purification and Stabilization of Factor V
Nature, 1963FACTOR V, a coagulation factor in plasma necessary for the conversion of prothrombin to thrombin, was discovered by Owren in 19431. The same type of activity as part of a hypothetic prothrombin complex was independently described by Quick2, who named it ‘labile factor’.
B, BLOMBACK, M, BLOMBACK
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