Results 141 to 150 of about 41,383 (293)
Chemistry – A European Journal, EarlyView.This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar +13 more
wiley +1 more source
Liver Transplantation, EarlyView., 2022 Abstract Patients with biliary atresia (BA) below 2 years of age in need of a transplantation largely rely on partial grafts from deceased donors (deceased donor liver transplantation [DDLT]) or living donors (living donor liver transplantation [LDLT]).
Hedayatullah Esmati +10 more
wiley +1 more source
Bleeding, Thrombosis and Vascular BiologyIntroduction. Cancer-associated thrombosis (CAT) is a frequent and clinically relevant complication in patients with malignancy. While inherited thrombophilia is a well-established risk factor for venous thromboembolism in the general population, its ...
Elena Campello
doaj
Light‐Induced Anion Translocation to Control Helical Folding in an Artificial Communication System
Chemistry – A European Journal, EarlyView.Anion‐induced helical folding of an oligomer is controlled indirectly and reversibly by light through anion uptake/release by a photoresponsive receptor. Thus, a light signal is processed into a chemical signal in a communication‐type three‐component supramolecular system.
Indigo M. Bekaert +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović +11 more
wiley +1 more source
Терапевтический архив, 2011 Aim. To estimate incidence of carriage of genetic polymorphisms coding hemostasis protein synthesis in patients with venous thromboembolic complications (VTEC) and healthy subjects in Moscow population; to detect VTEC genetic prognostic factors among the
Natal'ya Mikhaylovna Vorob'eva +11 more
doaj
A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders
Clinical Pharmacology &Therapeutics, EarlyView.Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel +3 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba +7 more
wiley +1 more source
Sustainable curriculum innovation through educational design research in conservatoire education
The Curriculum Journal, EarlyView.Abstract This study reported a four‐year educational design research (EDR) project at a Dutch conservatoire, where researchers and practitioners collaboratively redesigned the Bachelor of Music curriculum. Through iterative, practitioner‐led cycles of exploration, prototyping, implementation, and evaluation, the intervention produced a shared ...
Tamara Rumiantsev +2 more
wiley +1 more source
Emotion Regulation as a Predictor of Body Dissatisfaction in Individuals With Eating Disorders
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Body dissatisfaction (BD) plays a key role in the development and maintenance of eating disorders (EDs). BD might be influenced by emotion regulation. The maladaptive emotion regulation strategy suppression, aimed at inhibiting emotional responses, may increase BD by intensifying negative body‐related affect. Adaptive strategies like
Eline S. J. de Rijk +3 more
wiley +1 more source