Results 161 to 170 of about 13,721,448 (320)

Evaluating the Impact of Enhanced Stent Visualization on PCI Outcomes in Older Patients With Multivessel Disease

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Optimal stent expansion is a key determinant of long‐term outcomes after PCI. Intravascular imaging provides the most accurate assessment of stent deployment but remains underused, especially in older patients with MI and multivessel disease.
Marta Cocco, Alberto Sarti, Filippo Maria Verardi, Serena Caglioni, Jacopo Farina, Carlo Penzo, Carlo Tumscitz, Matteo Serenelli, Renè Tezze, Anna Cantone, Andrea Erriquez, Gianluca Campo, Simone Biscaglia   +12 more
wiley   +1 more source

Primary Percutaneous Coronary Intervention Guided by High‐Definition Intravascular Ultrasound (The SPECTRUM Study)

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Limited data are available on the use of intravascular ultrasound (IVUS) in patients presenting with ST‐segment elevation myocardial infarction (STEMI). Aims This study aimed to assess the impact of IVUS‐guided primary percutaneous coronary intervention (PCI).
Frederik T. W. Groenland, Annemieke C. Ziedses des Plantes, Tara Neleman, Jurgen M. R. Ligthart, Karen T. Witberg, Rutger‐Jan Nuis, Jeroen M. Wilschut, Roberto Diletti, Wijnand K. den Dekker, Isabella Kardys, Paul Cummins, Karim D. Mahmoud, Nicolas M. Van Mieghem, Joost Daemen   +13 more
wiley   +1 more source

Incidence of Factor V Leiden and Prothrombin Gene Polymorphisms as Risk Factors for Coronary Artery Disease in a Libyan Population: A Case–Control Study [PDF]

Ahlam M Ahbeel, Ahmed M Eshwika, Lutfi M Bakar, Mohamed S Abughren, Abdulrzag F. Ahmed   +4 more
openalex   +1 more source

Phosphonomethyl (Thio)Phosphonamidite Reagents for the Construction of Phosphonylmethyl Phosphono(Di)Thioate Mono‐ and Diesters

Chemistry – A European Journal, EarlyView.
A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić, Roy Steneker, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov   +4 more
wiley   +1 more source

Waitlist mortality of young patients with biliary atresia: Impact of allocation policy and living donor liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Patients with biliary atresia (BA) below 2 years of age in need of a transplantation largely rely on partial grafts from deceased donors (deceased donor liver transplantation [DDLT]) or living donors (living donor liver transplantation [LDLT]).
Hedayatullah Esmati, Marieke van Rosmalen, Patrick F. van Rheenen, Marieke T. de Boer, Aad P. van den Berg, Hubert P. J. van der Doef, Michel Rayar, Ruben H.J. de Kleine, Robert J. Porte, Vincent E. de Meijer, Henkjan J. Verkade   +10 more
wiley   +1 more source

Targeting Cancer Cells With Self‐Assembled Ru‐Polysaccharide Photocatalyst for Visible‐Light‐Induced Activation of Prodrugs

Chemistry – A European Journal, EarlyView.
Self‐assembled photocatalyst Ru(Ada‐bpy)(bpy)2⊂HACD targets cancer cells and catalyzes the prodrug to drug upon exposure to visible light, providing spatially and temporally control in cancer cells. This strategy achieves efficient, controllable, and targeted activation of prodrugs within cancer cells, laying the foundation of effectively reducing the ...
Jianghua Liu, Dinghao Wu, Alexander Kros, Joost N. H. Reek   +3 more
wiley   +1 more source

Factor V Leiden mutation and the risk of venous thromboembolism in pregnant women

Haematologica, 2001
BACKGROUND AND OBJECTIVES: In this retrospective, single center, cohort study we assessed the risk of pregnancy-related venous thromboembolism (VTE) in women belonging to a large number of families identified because of a symptomatic proband with single ...
D Tormene, P Simioni, P Prandoni, S Luni, P Zerbinati, D Sartor, F Franz, A Girolami   +7 more
doaj  

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Repurposing Registries: Completeness of Real‐World Data for Regulatory and HTA Purposes in Three Cancer‐Focused Registries

Clinical Pharmacology &Therapeutics, EarlyView.
Despite developments in supporting the identification and selection of fit‐for‐purpose registries, a translational gap remains between the original purposes of clinically focused registries and their current and future expected use in policymaking. This study aimed to assess the extent to which cancer‐focused registries collect essential data elements ...
Manon C. Wilpshaar, Doranne Hilarius, Luisa Prada, Ansgar Weltermann, Christine Leopold   +4 more
wiley   +1 more source

Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response—A Randomized, Placebo‐Controlled Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Mycophenolate mofetil (MMF) is an immunosuppressive drug widely used by solid organ transplant recipients. Although it is known that MMF suppresses immune responses, its exact effects on specific vaccinations have not been investigated yet. Mucosal vaccinations are increasingly used, such as a cholera vaccination consisting of two oral immunizations ...
Boukje C. Eveleens Maarse, Aliede E. in 't Veld, Hendrika W. Grievink, Manon A.A. Jansen, Matthijs Moerland   +4 more
wiley   +1 more source