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American Journal of Hematology, 1981
AbstractThis report describes three patients with factor (F) VII deficiency: two adult siblings and an unrelated 5½‐month‐old child who succumbed after several central nervous system (CNS) hemorrhages. This event prompted a review of the literature concerning the incidence and characteristics of intracranial hemorrhage in congenital F VII deficiency.Of
Ute Hasiba+3 more
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AbstractThis report describes three patients with factor (F) VII deficiency: two adult siblings and an unrelated 5½‐month‐old child who succumbed after several central nervous system (CNS) hemorrhages. This event prompted a review of the literature concerning the incidence and characteristics of intracranial hemorrhage in congenital F VII deficiency.Of
Ute Hasiba+3 more
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Molecular Variant of Factor VII [PDF]
SummaryTwo patients with severe factor VII deficiency appeared to be different with respect to the presence of inactive factor VH-like material in their plasma.The inactive material, demonstrated in one patient’s plasma and adsorbable onto BaSO4, inhibits the thrombotest-system and is capable of neutralizing a heterologous antibody against factor VII ...
Loeliger Ea+3 more
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Factor VII Survival Studies in Factor VII Padua Abnormality
Acta Haematologica, 1980Two patients with factor VII Padua abnormality were studied during prophylactic administration of factor VII concentrates for tooth extractions. The amounts administered were 15.8 and 17.2 units/kg body weight in 30 and 20 min, respectively. The end infusion factor VII activity levels were 55 and 64%, respectively.
F. Toffanin+2 more
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Factor VII activity and antigen in a patient with abnormal factor VII
Clinical & Laboratory Haematology, 1988A patient with abnormal factor VII, which showed different activity when thromboplastin from different sources was used, is reported. The propositus, who was first seen at routine health examination 1 month after delivery, was a girl with no complaints of bleeding.
Osamu Takamiya+5 more
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The Activation of Factor VII [PDF]
Native factor VII (F. VIIn) can be activated by thromboplastin or by the kallikrein-system. This gives rise to two different forms of activated factor VII. We thus discern Factor VIIn, cold activated factor VII (C.P.A-F. VIIa) and thromboplastin activated factor VII (T-F. VIIa).We developed one- and two-stage assays that distinguish between these forms
R. Gonggrijp, H. C. Hemker
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Clinical phenotypes and factor VII genotype in congenital factor VII deficiency
Thrombosis and Haemostasis, 2005SummaryTo investigate the relationship between clinical phenotype, clotting activity (FVIIc) and FVII genotype, a multi-center study of factor VII (FVII) congenital deficiency with centralized genotyping and specific functional assays was carried out. FVII mutations characterized in patients (n=313) were extremely heterogeneous (103 different, 22 novel)
MARIANI G+11 more
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Blood Coagulation & Fibrinolysis, 2003
To improve the standardization of the factor VII clotting activity (FVII:C) assay in patients treated with recombinant activated factor VII (rFVIIa), we conducted a multicentre study on plasma samples from four patients with haemophilia A, before and at various times after injection of a single dose of rFVIIa.
Claudine Caron+3 more
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To improve the standardization of the factor VII clotting activity (FVII:C) assay in patients treated with recombinant activated factor VII (rFVIIa), we conducted a multicentre study on plasma samples from four patients with haemophilia A, before and at various times after injection of a single dose of rFVIIa.
Claudine Caron+3 more
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Assessment of Factor VII and Factor X
Thrombosis and Haemostasis, 1966SummaryA method is described to separate factor VII from factor X in normal serum using electrophoresis in a polyvinyl chloride block. A potent source of factor X is obtained. This may be used in correction studies and for assessment of deficiencies of factor VII in patients.
Pegrum Gd+3 more
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How to Measure Factor VII and Factor VII Activation
Pathophysiology of Haemostasis and Thrombosis, 1983This communication describes the different techniques that can be used to evaluate the activity state of factor VII in plasma samples. At the present time direct methods for quantitation of activated factor VII (factor α-VIIa) are not available. Combined methods are therefore used to measure the degree of factor VII activation.
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Factor VII deficiency and its treatment in delivery with recombinant factor VII
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2004The authors present two cases of pregnant women with coagulation disorders--one with inherited deficiency of factor VII and the second with chronic hepatitis. Both cases were successfully treated with recombinant activated factor VII of coagulation (NovoSeven) in delivery. The advantages of using this product are discussed.
N. Milchev, B. Pehlivanov, G. Kroumov
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