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The Role of Phospholipids and the Factor VII Gla-Domain in the Interaction of Factor VII with Tissue Factor

Thrombosis and Haemostasis, 1992
SummaryWhether or not the factor VII Gla-domain is involved in the high-affinity interaction of factor VII and tissue factor via calcium-dependent interactions with surrounding phospholipids is unknown. To investigate this, we have purified the factor VII Gla-peptide (FVII-GP) from digested recombinant human factor VII a and assessed its effect on ...
Walter Kisiel   +5 more
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Factor VII and thromboembolism

Trends in Anaesthesia and Critical Care, 2018
Abstract Recombinant activated factor VIIa (rFVIIa) is a potent hemostatic agent originally developed for the treatment of haemophilia patients with inhibitors against factor FVIII or FIX. In approved indications, the safety profile of rFVIIa is favourable without major concerns.
Tiago Cardoso, Ayten Saracoglu
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Factor VII Hyperactivity in the Elderly

Thrombosis and Haemostasis, 1991
SummaryTo investigate the age-related increase in coagulation factor VII (FVII) and its significance in the elderly, we measured FVII coagulation activity (FVIIc), FVII antigen (FVIIag), and D-dimer levels in 150 normal subjects ranging in age from 60 to 98 years.
Takefumi Matsuo   +2 more
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Factor VII in an Industrial Population

British Journal of Haematology, 1974
Summary.Factor‐VII levels were measured in members of an industrial population participating in a long‐term prospective study of arterial disease. A modified semi‐automated method with an artificially prepared factor‐VII deficient plasma, one batch of freeze‐dried thromboplastin and one freeze‐dried pooled reference plasma was used throughout.
W R S North   +4 more
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Congenital factor VII deficiency

The Journal of Pediatrics, 1971
Summary A case of factor VII deficiency in a PuertoRican boy is described. He presented with epistaxis as the only symptom. The importance of early diagnosis of the defect is stressed. Identification of heterozygous carriers is also of importance because these persons, for unknown reasons, might present with hemorrhagic diathesis.
Maria L. Falter, Mary F. Kaufman
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Factor VII Deficiency

2018
This chapter outlines the pathophysiology, clinical presentation, inheritance, and incidence of factor VII deficiency. The chapter describes the interaction with pregnancy and discusses the medical and anesthetic management of pregnant women with factor VII deficiency, including treatment of acute hemorrhage.
Joanne Douglas, James P. R. Brown
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Factor VII in Liver Cirrhosis

Pathophysiology of Haemostasis and Thrombosis, 1982
Factor VII activity and factor VII cross-reacting material (CRM) in plasma of patients with liver cirrhosis have been studied before and after vitamin K<sub>1</sub> parenteral administration. Subjects were divided into two groups according to the absence (group I) or the presence (group II) of the following clinical findings: ascites ...
Renato Lauro   +5 more
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Congenital factor VII deficiency

The Indian Journal of Pediatrics, 2004
A 1(1/2)-month-old baby with seizures, lethargy and refusal of feeds was diagnosed to have intracranial hemorrhage due to factor VII deficiency. MRI also demonstrated the unusual presence of a hemorrhagic infarct. The case underscores the importance of carrying out neuroimaging and appropriate hematological studies even in the absence of obvious ...
Mamta N. Muranjan   +3 more
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Congenital deficiency of factor VII

The Indian Journal of Pediatrics, 1996
A case of congenital factor VII deficiency in a five-year-old child is reported. The patient, born of a non-consanguineous marriage, presented with repeated bouts of epistaxis since childhood. The prothrombin time (PT) was markedly prolonged with a normal bleeding time (BT), partial thromboplastin time with Kaolin (PTTK) and platelet count. The patient
Satendra Sharma   +4 more
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Factor VII deficiency and pregnancy

International Journal of Gynecology & Obstetrics, 1989
Hereditary factor VII deficiency is very rare in pregnancy (one in 500,000). However, obstetricians should consider this diagnosis whenever the prothrombin time is prolonged while the activated partial thromboplastin time is normal. The factor VII level increases in normal pregnancy, but the effect of pregnancy upon the factor VII level in deficient ...
JS Krauss, Hossam E Fadel
openaire   +3 more sources

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