Results 51 to 60 of about 14,512,458 (287)

Reduced thrombotic risk with recombinant factor VIIa in neonatal cardiac surgeryCentral MessagePerspective

JTCVS Open
Objective: The study objective was to assess the effect of intraoperative recombinant factor VII administration on postoperative outcomes in neonates. Methods: Neonates were identified who underwent arterial switch operation, tetralogy of Fallot repair ...
Harrison Higgins, BS, Carmel Falek, BS, Akshaya Sundaramurthy, MS, Eleonore Valencia, MD, Juan C. Ibla, MD, Aditya K. Kaza, MD, Peter Chiu, MD, MS   +6 more
doaj   +1 more source

Activation and control of factor VII by activated factor X and thrombin. Isolation and characterization of a single chain form of factor VII.

Journal of Biological Chemistry, 1975
Factor VII purified as previously described, was found to consist of two polypeptide chains joined by disulfide bridges. We now report the isolation and 200,000-fold purification of a single chain form of Factor VII.
R. Radcliffe, Y. Nemerson
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Fatal intracranial hemorrhage in a newborn with factor VII deficiency

The Turkish Journal of Pediatrics, 1996
Factor VII deficiency is a rare congenital coagulopathy. Prolonged prothrombin time with normal partial thromboplastin time indicates factor VII deficiency. For the definitive diagnosis, the specific factor VII level should be investigated.
R Uçsel, S Savaşan, A Coban, F Metin, G Can   +4 more
doaj  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Newly diagnosed congenital factor VII deficiency and utilization of recombinant activated factor VII (NovoSeven®)

Clinical Pharmacology: Advances and Applications, 2013
Nicole S Bartosh, Tara Tomlin, Christian Cable, Kathleen HalkaDepartment of Internal Medicine, Division of Medical Oncology, Scott and White Healthcare and Texas A and M Health Science Center College of Medicine, Temple, TX, USAAbstract: This case report
Bartosh NS, Tomlin T, Cable C, Halka K
doaj  

THE EFFICACY OF RECOMBINANT ACTIVATED FACTOR VII (COAGIL VII) FOR TREATMENT HAEMORRHAGE AND HAEMOSTASIS DISORDES DURING THORACIC AORTA OPERATIONS

Вестник анестезиологии и реаниматологии, 2019
Goal: to evaluate the efficacy and safety of domestic (home-produced) recombinant factor VIIa (Coagil VII) for massive bleeding and haemostasis disordes treatment in thoracic aorta surgery. Methods.
N. A. TREKOVA, D. A. GUSKOV, A. V. GONCHAROVA, B. A. AKSELROD   +3 more
doaj   +1 more source

Kinetics of the activation of bovine coagulation factor X by components of the extrinsic pathway. Kinetic behavior of two-chain factor VII in the presence and absence of tissue factor.

Journal of Biological Chemistry, 1977
A new assay for the activation of bovine coagulation Factor X by two-chain Factor VII (cu-VIIa) is described. The assay measures the release of the radiolabeled activation peptide which is soluble in 5% trichloroacetic acid.
S. A. Silverberg, Y. Nemerson, M. Zur
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Assessment of Factor VII Levels in Patients of Chronic Liver Disease

Journal of Rawalpindi Medical College, 2013
Background : To determine the levels of coagulation factor VII in patients of chronic liver disease. Methods: In this descriptive study sixty known patients of chronic liver disease were included.
Nabeela Naeem
doaj