Results 41 to 50 of about 12,736,036 (293)

Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

Research and Practice in Thrombosis and Haemostasis, 2020
Hemostasis is a complex process involving the concerted action of molecular and vascular components. Its basic understanding as well as diagnostic and therapeutic aspects have greatly benefited from the use of monoclonal antibodies.
Ivan Peyron, Claire Kizlik‐Masson, Marie‐Daniéla Dubois, Sénadé Atsou, Stephen Ferrière, Cécile V. Denis, Peter J. Lenting, Caterina Casari, Olivier D. Christophe   +8 more
doaj   +1 more source

Adiponectin alleviate blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): The purpose of this study was to detect the protective effects of adiponectin on coagulation dysfunction and its mechanism in sepsis of rats.Materials and Methods: The experimental samples were composed of sham group,   model group that was
Yun Hou, Xi-Feng Wang, Zhi-Qiang Lang, Wei Zhao, Yinchuan Jin, Hong-Qin Zhang, Lian-Shuang Zhang   +6 more
doaj   +1 more source

AryoSeven RT (Coagulation factor VIIa, recombinant) safety and efficacy study among congenial factor VII deficient patients in Iraq

Iraqi Journal of Hematology, 2022
BACKGROUND: Recombinant activated factor VII (FVII) is a product onetime evolved to stop bleeding occurring in hemophilia A and B patients with inhibitor, congenital FVII deficiency, Glanzmann disease, and in life-threatening bleeding.
Nidal Karim Al-Rahal, Ahmed Shemran Alwataify, Safa Mohammed Shawkat, Israa Almusawi, Azeezah Mohammed Mohsin   +4 more
doaj   +1 more source

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

Gain of 20q11.21 in human pluripotent stem cells impairs TGF-β-dependent neuroectodermal commitment [PDF]

, 2019
Gain of 20q11.21 is one of the most common recurrent genomic aberrations in human pluripotent stem cells. Although it is known that overexpression of the antiapoptotic gene Bcl-xL confers a survival advantage to the abnormal cells, their differentiation ...
De Deckersberg, E. Couvreu, De Kock, J., Dziedzicka, D., Franceschini, L., Geens, M., Keller, A., Markouli, C., Nguyen, H. T., Regin, M., Sermon, K., Spits, C., Tilleman, Laurentijn, Van Nieuwerburgh, Filip, Zambelli, F.   +13 more
core   +1 more source

Microporous Microgel Assemblies Facilitating the Recruitment and Osteogenic Differentiation of Progenitor Cells for Bone Regeneration

Advanced Functional Materials, EarlyView.
There is a significant need for biomaterials with well‐defined stability and bioactivity to support tissue regeneration. In this study, we developed a tunable microgel platform that enables the decoupling of stiffness from porosity, thereby promoting bone regeneration.
Silvia Pravato, Haishuo Guan, Bianca M. Carrara, Mira Jacobs, Matteo Monticelli, Lukas Moser, Thomas Moragues, Andrew J. deMello, Tomaso Zambelli, Martin Ehrbar   +9 more
wiley   +1 more source

Pharmacological characteristics of a novel, recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP)

Journal of Thrombosis and Haemostasis, 2014
Recombinant factor VIIa (rFVIIa) is approved for use in controlling bleeding episodes in people with hemophilia who have developed inhibitors to replacement therapy. Due to its short half‐life (t½), frequent injections are required, limiting its use as a
S. Zollner, D. Schuermann, E. Raquet, J. Mueller-Cohrs, T. Weimer, I. Pragst, G. Dickneite, S. Schulte   +7 more
semanticscholar   +1 more source

Control of disseminated intravascular coagulation in Klippel-Trenaunay-Weber syndrome using enoxaparin and recombinant activated factor VIIa: a case report

Journal of Medical Case Reports, 2010
Introduction Vascular malformation is associated with coagulopathies, especially when hemostasis is challenged. Case presentation We present the case of an 11-year-old Hispanic girl with Klippel-Trenaunay-Weber syndrome that developed disseminated ...
Kecskes Susan, Hast Howard, Schmidt Mary, Beier Ulf H, Valentino Leonard A   +4 more
doaj   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

The Eph Tyrosine Kinase Receptors EphB2 and EphA2 Are Novel Proteolytic Substrates of Tissue Factor/Coagulation Factor VIIa*

Journal of Biological Chemistry, 2014
Background: The tissue factor/coagulation factor VIIa (TF/FVIIa) complex cleaves protease-activated receptor 2 (PAR2), but other non-coagulant substrates are not known.
O. Eriksson, M. Ramström, K. Hörnaeus, J. Bergquist, Dariush Mokhtari, A. Siegbahn   +5 more
semanticscholar   +1 more source