Results 121 to 130 of about 13,061,190 (344)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The Clinical Application of Feiba Immuno in Factor VIII Inhibitor Patients [PDF]

, 1977
K. Anderle
openalex   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Factor VIII-Mimetic Function of Humanized Bispecific Antibody in Hemophilia A.

New England Journal of Medicine, 2016
M. Shima, H. Hanabusa, M. Taki, T. Matsushita, Tetsuji Sato, K. Fukutake, Naoki Fukazawa, K. Yoneyama, Hiroki Yoshida, K. Nogami   +9 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Novel, human cell line‐derived recombinant factor VIII (human‐cl rhFVIII; Nuwiq^®) in adults with severe haemophilia A: efficacy and safety [PDF]

, 2015
Toshko Lissitchkov, K. K. Hampton, Mario von Depka, C. R. M. Hay, Savita Rangarajan, Edward G. D. Tuddenham, Katharina Holstein, Angela Huth‐Kühne, Ingrid Pabinger, Sigurd Knaub, J. Bichler, Johannes Oldenburg   +11 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Mobilization mechanism of von Willebrand Factor (VIII VWF) from the platelets and its significance in Thrombogenesis

, 1978
Minako KAJIKAWA, Yoshinori TAKETOMI, Kingo Fujimura, Akihiro Ihara, Naosada WAKASA, Atsushi Kuramoto   +5 more
openalex   +2 more sources

Short incubation non-A, non-B hepatitis transmitted by factor VIII concentrates in patients with congenital coagulation disorders. [PDF]

, 1981
M Bamber, Alison D. Murray, Bengt Arborgh, Peter J. Scheuer, P. B. A. Kernoff, Howard C. Thomas, Sheila Sherlock   +6 more
openalex   +1 more source

A Closed-Tube Nested Quantitative PCR Assay for Rapid Detection of Intron 22 Inversions in the Factor VIII Gene [PDF]

, 2020
Shengnan Jin, Qingjuan Shang, Weijiang Jin, Yang Liu-qing, Qian Ye, Xi Wang, Tianran Zhang, Mingliang Hou, Yangyang Liu, Jiamin Han, Rongxiu Ding, Ju Luan, Xuefeng Wang, Minghua Jiang, Chunming Ding   +14 more
openalex   +1 more source