Results 21 to 30 of about 257,618 (243)
User-Centered Design (VIII): A New Framework of Intelligent Sociotechnical Systems and Prospects for Future Human Factors Research [PDF]
arXiv, 2022 Traditional sociotechnical systems (STS) theory has been widely used, but there are many new characteristics in the STS environment as we enter the intelligence era, resulting in the limitations of traditional STS. Based on the "user-centered design" philosophy, this paper proposes a new framework of intelligent sociotechnical systems (iSTS) and ...
arxiv
Cos observations of metal line and broad lyman alpha absorption in the multi-phase o vi and ne viii system toward he 02226-4110 [PDF]
, 2011 Observations of the QSO HE 0226-4110 (zem = 0.495) with the Cosmic Origins Spectrograph (COS) from 1134 to 1796 {\AA} with a resolution of ~17 km s-1 and signal-to- noise (S/N) per resolution element of 20 to 40 are used to study the multi-phase absorption system at z = 0.20701 containing O VI and Ne VIII. The system was previously studied with lower S/
arxiv +1 more source
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
Elastic Form Factors in Point-form Approach [PDF]
, 2000 Using the point-form approach to relativistic quantum mechanics, a covariant framework is presented for the calculation of proton and neutron electromagnetic form factors. Results for charge radii, magnetic moments, and electric as well as magnetic form factors are produced using the wave functions obtained in the so-called Goldstone-boson-exchange ...
arxiv +1 more source
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Core-valence correlations for atoms with open shells [PDF]
Phys. Rev. A 75, 052504 (2007), 2007 We present an efficient method of inclusion of the core-valence correlations into the configuration interaction (CI) calculations. These correlations take place in the core area where the potential of external electrons is approximately constant. A constant potential does not change the core electron wave functions and Green's functions. Therefore, all
arxiv +1 more source
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022 Abstract Background Ultrasonography (US) and 99mTechnetium‐sestamibi scintigraphy (99mTc‐MIBI) are currently first‐line imaging modalities to localize parathyroid adenomas with sensitivities of 80% and 84%, respectively. Therefore, finding other modalities to further improve the diagnostic accuracy for preoperative localization is critically needed ...
Fangyi Liu +7 more
wiley +1 more source