Results 21 to 30 of about 14,336,962 (399)
Case Reports in Rheumatology, 2021 Acquired factor VIII deficiency is a bleeding disorder caused by the presence of autoantibodies against clotting factor VIII. We report a case of a 24-year-old pregnant woman who presented with gross hematuria secondary to acquired factor VIII deficiency
Christine Loftis +2 more
doaj +1 more source
Pakistan Armed Forces Medical Journal, 2021 Objective: To evaluate the efficacy of recombinant factor VIII FC fusion protein in haemophilia A patient receiving on demand treatment only. Study Design: Comparative cross sectional study.
Saima Zahir +5 more
doaj +1 more source
Permanent cell line expressing human factor VIII-related antigen established by hybridization.
Proceedings of the National Academy of Sciences of the United States of America, 1983 A permanent human cell line, EA . hy 926, has been established that expresses at least one highly differentiated function of vascular endothelium, factor VIII-related antigen.
C. Edgell, C. C. McDonald, J. Graham
semanticscholar +1 more source
Frontiers in Immunology, 2020 The development of an immune response against therapeutic factor VIII is the major complication in hemophilia A patients. Oligomannose carbohydrates at N239 and/or N2118 on factor VIII allow its binding to the macrophage mannose receptor expressed on ...
Sandrine Delignat +8 more
doaj +1 more source
Isolation and primary cultures of human intrahepatic bile ductular epithelium [PDF]
, 1988 A technique for the isolation of human intrahepatic bile ductular epithelium, and the establishment of primary cultures using a serum- and growth-factor-supplemented medium combined with a connective tissue substrata is described.
A. E. Sirica +24 more
core +1 more source
Journal of Thrombosis and Haemostasis, 2018 Essentials Elevated procoagulant levels are associated with an increased risk of venous thrombosis (VT). The dependency on concurrent increased factor levels and VT was analyzed in a large study.
I. M. Rietveld +6 more
semanticscholar +1 more source
The effects of different alcoholic drinks on lipids, insulin and haemostatic and inflammatory markers in older men [PDF]
, 2003 Light to moderate drinking is associated with lower risk of coronary heart (CHD) than non-drinkers. We have examined the relationships between total alcohol intake and type of alcoholic beverage and several potential biological mechanisms. We carried out
Lennon, L. +6 more
core +1 more source
Factor VIII-Mimetic Function of Humanized Bispecific Antibody in Hemophilia A.
New England Journal of Medicine, 2016 BACKGROUND In patients with severe hemophilia A, standard treatment is regular prophylactic and episodic intravenous infusions of factor VIII. However, these treatments are burdensome, especially for children, and may lead to the formation of anti-factor
M. Shima +9 more
semanticscholar +1 more source
Haematologica, 2019 Therapeutic factor VIII is highly immunogenic. Despite intensive research in the last decades, the reasons why 5-30% of patients with hemophilia A (of all severities) develop inhibitory anti-factor VIII antibodies (inhibitors) following replacement ...
Aditi Varthaman +1 more
doaj +1 more source
Inhibitors in Patients with Congenital Bleeding Disorders Other Than Hemophilia [PDF]
, 2017 The most worrying complication of replacement therapy for severe hemophilia A and B is currently the occurrence of inhibitory alloantibodies against infused factor VIII and factor IX, respectively.
Franchini, Massimo +6 more
core +1 more source