Results 31 to 40 of about 14,299,063 (394)
Haematologica, 2019 Hemophilia A is a rare hemorrhagic disorder caused by the lack of functional pro-coagulant factor VIII. Factor VIII replacement therapy in patients with severe hemophilia A results in the development of inhibitory anti-factor VIII IgG in up to 30% of ...
Sandrine Delignat +7 more
doaj +1 more source
Pakistan Armed Forces Medical Journal, 2021 Objective: To evaluate the efficacy of recombinant factor VIII FC fusion protein in haemophilia A patient receiving on demand treatment only. Study Design: Comparative cross sectional study.
Saima Zahir +5 more
doaj +1 more source
A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A.
New England Journal of Medicine, 2016 BACKGROUND The development of neutralizing anti-factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy.
F. Peyvandi +46 more
semanticscholar +1 more source
Frontiers in Immunology, 2020 The development of an immune response against therapeutic factor VIII is the major complication in hemophilia A patients. Oligomannose carbohydrates at N239 and/or N2118 on factor VIII allow its binding to the macrophage mannose receptor expressed on ...
Sandrine Delignat +8 more
doaj +1 more source
Ab initio studies on the lattice thermal conductivity of silicon clathrate frameworks II and VIII [PDF]
Phys. Rev. B 93, 024307 (2016), 2015 The lattice thermal conductivities of silicon clathrate frameworks II and VIII are investigated by using ab initio lattice dynamics and iterative solution of the linearized Boltzmann transport equation(BTE) for phonons. Within the temperature range 100-350 K, the clathrate structures II and VIII were found to have lower lattice thermal conductivity ...
arxiv +1 more source
Permanent cell line expressing human factor VIII-related antigen established by hybridization.
Proceedings of the National Academy of Sciences of the United States of America, 1983 A permanent human cell line, EA . hy 926, has been established that expresses at least one highly differentiated function of vascular endothelium, factor VIII-related antigen.
C. Edgell, C. C. McDonald, J. Graham
semanticscholar +1 more source
Journal of Thrombosis and Haemostasis, 2018 Essentials Elevated procoagulant levels are associated with an increased risk of venous thrombosis (VT). The dependency on concurrent increased factor levels and VT was analyzed in a large study.
I. M. Rietveld +6 more
semanticscholar +1 more source
Galaxy cluster photons alter the ionisation state of the nearby warm-hot intergalactic medium [PDF]
, 2022 The physical properties of the faint and extremely tenuous plasma in the far outskirts of galaxy clusters, the circumgalactic media of normal galaxies, and filaments of the cosmic web, remain one of the biggest unknowns in our story of large-scale structure evolution. Modelling the spectral features due to emission and absorption from this very diffuse
arxiv +1 more source
Nonequilibrium Response and Frenesy [PDF]
Journal of Physics: Conference Series 638, 012001 (2015), 2015 We present examples of how time-symmetric kinetic factors contribute to the response either in nonlinear order around equilibrium or in linear order around nonequilibrium. The phenomenology we associate to that so called frenetic contribution are negative differential conductivity, changes in the Einstein relation between friction and noise, and ...
arxiv +1 more source
Factor VIII-Mimetic Function of Humanized Bispecific Antibody in Hemophilia A.
New England Journal of Medicine, 2016 BACKGROUND In patients with severe hemophilia A, standard treatment is regular prophylactic and episodic intravenous infusions of factor VIII. However, these treatments are burdensome, especially for children, and may lead to the formation of anti-factor
M. Shima +9 more
semanticscholar +1 more source